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Tbio
DSG4
Desmoglein-4

Protein Summary
Description
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308128
  • ENSP00000311859
  • ENSG00000175065
  • ENST00000359747
  • ENSP00000352785

Symbol
  • CDHF13
  • LAH
  • HYPT6
  • CDGF13
  • CDHF13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
interacting protein
0.68
cell line
0.61
phenotype
0.46
metabolite
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.02   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.02   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
susceptibility to vaginal yeast infection measurement
1
1
1
66.8
vitamin D measurement
3
2
3
57.1
1
1
0
5.5
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
susceptibility to vaginal yeast infection measurement
1
66.8
vitamin D measurement
3
57.1
0
5.5
14.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
desmoglein 4
VGNC:5161
743297
Macaque
desmoglein 4
713015
Mouse
MGI:2661061
16769
Rat
RGD:735015
291754
Dog
desmoglein 4
VGNC:40108
612592
Species
Name
OMA
EggNOG
Inparanoid
Chimp
desmoglein 4
Macaque
desmoglein 4
Mouse
Rat
Dog
desmoglein 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86SJ6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (51)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (126)
1 – 10 of 126
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.999975733
p_ni:  0.000024267
Data Source:  BioPlex
IL31RA
Tbio
Novelty:  0.00737445
p_int:  0.999945876
p_ni:  0.000054124
Data Source:  BioPlex
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  0.999877839
p_ni:  0.000122146
p_wrong:  1.4e-8
Data Source:  BioPlex
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.999824754
p_ni:  0.000175246
Data Source:  BioPlex
FBXO3
Tbio
Novelty:  0.01701102
p_int:  0.999808213
p_ni:  0.000191778
p_wrong:  1e-8
Data Source:  BioPlex
TFG
Tbio
Novelty:  0.00320616
p_int:  0.999794577
p_ni:  0.000205423
Data Source:  BioPlex
RPN2
Tbio
Family:  Enzyme
Novelty:  0.01796569
p_int:  0.999698165
p_ni:  0.000301834
Data Source:  BioPlex
LAIR2
Tbio
Novelty:  0.06117644
p_int:  0.998956913
p_ni:  0.001043084
p_wrong:  4e-9
Data Source:  BioPlex
PYHIN1
Tbio
Novelty:  0.06662677
p_int:  0.998725124
p_ni:  0.001274862
p_wrong:  1.4e-8
Data Source:  BioPlex
OR51E2
Tchem
Family:  oGPCR
Novelty:  0.02435259
p_int:  0.998312709
p_ni:  0.001687269
p_wrong:  2.2e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  57.02

PubMed score by year
PubTator Score  39.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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