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Tchem
NEK8
Serine/threonine-protein kinase Nek8

Protein Summary
Description
Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268766
  • ENSP00000268766
  • ENSG00000160602

Symbol
  • JCK
  • NEK12A
  • JCK
  • NPHP9
  • RHPD2
  • NEK12A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor binding site profile
0.94
protein domain
0.92
gene perturbation
0.88
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.12   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.12   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (64)
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
Score:  0.914
Data Source:  STRINGDB
INVS
Tbio
Novelty:  0.00834489
Score:  0.873
Data Source:  STRINGDB
ANKS6
Tbio
Novelty:  0.05822758
Score:  0.864
Data Source:  STRINGDB
ANKS3
Tbio
Novelty:  0.19978252
Score:  0.852
Data Source:  STRINGDB
NPHP3
Tbio
Novelty:  0.02857926
Score:  0.836
Data Source:  STRINGDB
NPHP4
Tbio
Novelty:  0.02873746
Score:  0.83
Data Source:  STRINGDB
CEP290
Tbio
Novelty:  0.00526375
Score:  0.804
Data Source:  STRINGDB
NEK7
Tchem
Family:  Kinase
Novelty:  0.02675561
Score:  0.776
Data Source:  STRINGDB
NEK6
Tchem
Family:  Kinase
Novelty:  0.02394134
Score:  0.754
Data Source:  STRINGDB
NPHP1
Tbio
Novelty:  0.01113034
Score:  0.709
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
85.3
hemoglobin measurement
2
2
2
84.3
mean corpuscular hemoglobin concentration
1
1
1
83.2
reticulocyte count
2
2
2
83
reticulocyte measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
85.3
hemoglobin measurement
2
84.3
mean corpuscular hemoglobin concentration
1
83.2
reticulocyte count
2
83
reticulocyte measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1890646
140859
Rat
RGD:1306897
287473
Dog
NIMA related kinase 8
491171
Horse
NIMA related kinase 8
100059451
Cow
NIMA related kinase 8
532332
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
NIMA related kinase 8
Horse
NIMA related kinase 8
Cow
NIMA related kinase 8
Publication Statistics
PubMed Score 139.12
PubMed score by year
PubTator Score 30.96
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title