Tbio S100A7A Protein S100-A7A

Protein Summary

Description

May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.

Uniprot Accession IDs

• Q86SG5
• D3DV38
• Q5SY69

Gene Name

• S100A7A

Ensembl ID

• ENST00000329256
• ENSP00000329008
• ENSG00000184330
• ENST00000368728
• ENSP00000357717
• ENST00000368729
• ENSP00000357718

Symbol

• S100A15
• S100A7L1
• NICE2
• NICE-2
• S100A15
• S100A7f
• S100A7L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
microRNA	0.6
protein complex	0.45
cell line	0.42
transcription factor	0.42

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein S100-a7a

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Protein S100-a7a

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Protein S100-a7a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.3   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.3   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (34)

Explore Interacting Targets

1 – 10 of 34

• See Interactions on String-DB

FMOD

Tbio

Novelty:  0.00459438

p_int:  0.999995588

p_ni:  0.000004408

p_wrong:  4e-9

Data Source:  BioPlex

TBC1D22B

Tbio

Novelty:  0.49852962

p_int:  0.999992868

p_ni:  3.51e-7

p_wrong:  0.000006782

Data Source:  BioPlex

CDK15

Tchem

Family:  Kinase

Novelty:  0.3870338

p_int:  0.999991139

p_ni:  0.000005626

p_wrong:  0.000003235

Data Source:  BioPlex

SUSD3

Tdark

Novelty:  0.43699506

p_int:  0.999973951

p_ni:  0.000026049

p_wrong:  1e-9

Score:  0.211

Data Source:  BioPlex,STRINGDB

RASGEF1C

Tdark

Novelty:  0.93266395

p_int:  0.999844302

p_ni:  0.000090117

p_wrong:  0.000065581

Score:  0.485

Data Source:  BioPlex,STRINGDB

FMNL2

Tbio

Novelty:  0.03453161

p_int:  0.999840045

p_ni:  0.000065306

p_wrong:  0.000094649

Data Source:  BioPlex

CCNYL1

Tdark

Novelty:  0.45350824

p_int:  0.999798662

p_ni:  0.000116941

p_wrong:  0.000084396

Score:  0.183

Data Source:  BioPlex,STRINGDB

KLHL11

Tbio

Novelty:  0.1537041

p_int:  0.999741052

p_ni:  0.000001933

p_wrong:  0.000257014

Data Source:  BioPlex

UGT1A10

Tbio

Family:  Enzyme

Novelty:  0.01535804

p_int:  0.998892784

p_ni:  0.000133863

p_wrong:  0.000973354

Score:  0.234

Data Source:  BioPlex,STRINGDB

CRCT1

Tbio

Novelty:  0.09048426

Score:  0.694

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (4)

Antimicrobial peptides (R-HSA-6803157)

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5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antimicrobial peptides	89 targets	R-HSA-6803157
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Metal sequestration by antimicrobial proteins	6 targets	R-HSA-6799990

Name	Explore in Pharos	Explore in Source
Antimicrobial peptides	89 targets	R-HSA-6803157
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Metal sequestration by antimicrobial proteins	6 targets	R-HSA-6799990

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
protein self-association	Inferred from Direct Assay (IDA)	MGI
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro
transition metal ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil percentage of leukocytes	EFO_0007990	1	1	1		38.2
monocyte percentage of leukocytes	EFO_0007989	2	1	2		34.8
monocyte count	EFO_0005091	1	1	1		28
basophil percentage of leukocytes	EFO_0007992	1	1	1		17
matrix metalloproteinase 8 measurement	EFO_0008466	1	1	1		14.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil percentage of leukocytes	EFO_0007990	1		38.2
monocyte percentage of leukocytes	EFO_0007989	2		34.8
monocyte count	EFO_0005091	1		28
basophil percentage of leukocytes	EFO_0007992	1		17
matrix metalloproteinase 8 measurement	EFO_0008466	1		14.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Calcium
Complete proteome
Cytoplasm
Metal-binding
Polymorphism
Reference proteome
Repeat
Zinc

GWAS Trait Find Similar Targets

No Header	No Header
basophil percentage of leukocytes
granulocyte percentage of myeloid white cells
high density lipoprotein cholesterol measurement
matrix metalloproteinase 8 measurement
monocyte count
monocyte percentage of leukocytes
neutrophil percentage of leukocytes
sleep duration

IDG Resources

No IDG generated resources found

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Horse	S100 calcium binding protein A7		100033976
Cow	S100 calcium binding protein A7		282344

Species	Name	OMA	EggNOG	Inparanoid
Horse	S100 calcium binding protein A7
Cow	S100 calcium binding protein A7

Publication Statistics

PubMed Score 15.30

PubMed score by year

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PubTator Score 17.73

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (6)

Items per page:

10

0 of 0

PMID	Year	Title