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Tbio
S100A7A
Protein S100-A7A

Protein Summary
Description
May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329256
  • ENSP00000329008
  • ENSG00000184330
  • ENST00000368728
  • ENSP00000357717
  • ENST00000368729
  • ENSP00000357718

Symbol
  • S100A15
  • S100A7L1
  • NICE2
  • NICE-2
  • S100A15
  • S100A7f
  • S100A7L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
microRNA
0.6
protein complex
0.45
cell line
0.42
transcription factor
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.3   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.3   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
FMOD
Tbio
Novelty:  0.00459438
p_int:  0.999995588
p_ni:  0.000004408
p_wrong:  4e-9
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.999992868
p_ni:  3.51e-7
p_wrong:  0.000006782
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.999991139
p_ni:  0.000005626
p_wrong:  0.000003235
Data Source:  BioPlex
SUSD3
Tdark
Novelty:  0.43699506
p_int:  0.999973951
p_ni:  0.000026049
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
RASGEF1C
Tdark
Novelty:  0.93266395
p_int:  0.999844302
p_ni:  0.000090117
p_wrong:  0.000065581
Score:  0.485
Data Source:  BioPlex,STRINGDB
FMNL2
Tbio
Novelty:  0.03453161
p_int:  0.999840045
p_ni:  0.000065306
p_wrong:  0.000094649
Data Source:  BioPlex
CCNYL1
Tdark
Novelty:  0.45350824
p_int:  0.999798662
p_ni:  0.000116941
p_wrong:  0.000084396
Score:  0.183
Data Source:  BioPlex,STRINGDB
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.999741052
p_ni:  0.000001933
p_wrong:  0.000257014
Data Source:  BioPlex
UGT1A10
Tbio
Family:  Enzyme
Novelty:  0.01535804
p_int:  0.998892784
p_ni:  0.000133863
p_wrong:  0.000973354
Score:  0.234
Data Source:  BioPlex,STRINGDB
CRCT1
Tbio
Novelty:  0.09048426
Score:  0.694
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metal sequestration by antimicrobial proteins
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Metal sequestration by antimicrobial proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
38.2
monocyte percentage of leukocytes
2
1
2
34.8
monocyte count
1
1
1
28
basophil percentage of leukocytes
1
1
1
17
matrix metalloproteinase 8 measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
38.2
monocyte percentage of leukocytes
2
34.8
monocyte count
1
28
basophil percentage of leukocytes
1
17
matrix metalloproteinase 8 measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
S100 calcium binding protein A7
100033976
Cow
S100 calcium binding protein A7
282344
Species
Name
OMA
EggNOG
Inparanoid
Horse
S100 calcium binding protein A7
Cow
S100 calcium binding protein A7
Publication Statistics
PubMed Score 15.30
PubMed score by year
PubTator Score 17.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title