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Tbio
GALNT7
N-acetylgalactosaminyltransferase 7

Protein Summary
Description
Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265000
  • ENSP00000265000
  • ENSG00000109586

Symbol
  • GalNAcT7
  • GALNAC-T7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
microRNA
0.83
transcription factor perturbation
0.8
transcription factor binding site profile
0.74
PubMedID
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.01   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.01   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
1
2
72.2
alcohol use disorder measurement
1
1
1
57.4
self reported educational attainment
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
72.2
alcohol use disorder measurement
1
57.4
self reported educational attainment
1
52
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 7
VGNC:50349
740702
Macaque
polypeptide N-acetylgalactosaminyltransferase 7
696924
Mouse
MGI:1349449
108150
Rat
RGD:620362
29750
Dog
polypeptide N-acetylgalactosaminyltransferase 7
486771
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 7
Macaque
polypeptide N-acetylgalactosaminyltransferase 7
Mouse
Rat
Dog
polypeptide N-acetylgalactosaminyltransferase 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86SF2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Protein-Protein Interactions (79)
1 – 10 of 79
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00096678
p_int: 0.999841265
p_ni: 0.000157983
p_wrong: 7.52e-7
Score: 0.195
Data Source: BioPlex,STRINGDB
REEP5
Tbio
Novelty: 0.00160455
p_int: 0.99952038
p_ni: 0.00047962
Data Source: BioPlex
TCTN2
Tbio
Novelty: 0.11617528
p_int: 0.996117991
p_ni: 0.003882009
Data Source: BioPlex
ADPGK
Tbio
Family: Kinase
Novelty: 0.0552414
p_int: 0.986124898
p_ni: 0.013875102
Score: 0.522
Data Source: BioPlex,STRINGDB
GALNT12
Tbio
Family: Enzyme
Novelty: 0.085131
p_int: 0.977625115
p_ni: 0.022374867
p_wrong: 1.8e-8
Score: 0.453
Data Source: BioPlex,STRINGDB
SLC3A2
Tbio
Family: Transporter
Novelty: 0.0021506
p_int: 0.952935158
p_ni: 0.047064681
p_wrong: 1.61e-7
Data Source: BioPlex
MPPE1
Tbio
Family: Enzyme
Novelty: 0.16027847
p_int: 0.922426887
p_ni: 0.077573113
Data Source: BioPlex
MAN2A2
Tbio
Family: Enzyme
Novelty: 0.07098345
p_int: 0.913173938
p_ni: 0.086453482
p_wrong: 0.00037258
Score: 0.429
Data Source: BioPlex,STRINGDB
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.905534192
p_ni: 0.094465808
Data Source: BioPlex
GALNT4
Tbio
Family: Enzyme
Novelty: 0.05200323
p_int: 0.900886652
p_ni: 0.000847417
p_wrong: 0.098265931
Score: 0.837
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  17.01

PubMed score by year
PubTator Score  8.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer