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Tdark
PCGF5
Polycomb group RING finger protein 5

Protein Summary
Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336126
  • ENSP00000337500
  • ENSG00000180628
  • ENST00000543648
  • ENSP00000445704
  • ENST00000614189
  • ENSP00000479492

Symbol
  • RNF159
  • RNF159
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.99
cellular component
0.78
microRNA
0.76
transcription factor binding site profile
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
6
6
76.5
hematocrit
1
1
1
53.3
hemoglobin measurement
1
1
1
52.7
smoking behaviour measurement
1
1
1
29
body height
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
76.5
hematocrit
1
53.3
hemoglobin measurement
1
52.7
smoking behaviour measurement
1
29
body height
1
21.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polycomb group ring finger 5
VGNC:5589
466157
Mouse
MGI:1923505
76073
Rat
RGD:1583513
681178
Dog
polycomb group ring finger 5
VGNC:44303
486794
Horse
polycomb group ring finger 5
100062041
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polycomb group ring finger 5
Mouse
Rat
Dog
polycomb group ring finger 5
Horse
polycomb group ring finger 5
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86SE9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Reactome
Transcriptional regulation by RUNX1
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Transcriptional regulation by RUNX1
Protein-Protein Interactions (64)
1 – 10 of 64
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999999998
p_ni:  2e-9
Score:  0.971
Data Source:  BioPlex,STRINGDB
RYBP
Tbio
Novelty:  0.01140945
p_int:  0.999999815
p_ni:  1.85e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
FBRS
Tbio
Novelty:  0.13646817
p_int:  0.999999683
p_ni:  3.09e-7
p_wrong:  9e-9
Score:  0.914
Data Source:  BioPlex,STRINGDB
AUTS2
Tbio
Novelty:  0.01782909
p_int:  0.999999348
p_ni:  6.5e-7
p_wrong:  2e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
YAF2
Tbio
Novelty:  0.10772286
p_int:  0.999994695
p_ni:  3.76e-7
p_wrong:  0.000004929
Score:  0.994
Data Source:  BioPlex,STRINGDB
RNF2
Tbio
Family:  Enzyme
Novelty:  0.00859204
p_int:  0.998333244
p_ni:  0.001666756
Score:  0.996
Data Source:  BioPlex,STRINGDB
RING1
Tbio
Family:  Enzyme
Novelty:  0.00729948
p_int:  0.994251681
p_ni:  0.005748319
Score:  0.996
Data Source:  BioPlex,STRINGDB
CSNK2A1
Tchem
Family:  Kinase
Novelty:  0.00187855
p_int:  0.988815653
p_ni:  0.011184347
Score:  0.969
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.895518132
p_ni:  0.104474052
p_wrong:  0.000007817
Score:  0.97
Data Source:  BioPlex,STRINGDB
CBX7
Tchem
Family:  Epigenetic
Novelty:  0.01612606
Score:  0.965
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.00

PubMed score by year
PubTator Score  3.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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