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Tdark
TMEM179B
Transmembrane protein 179B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333449
  • ENSP00000333697
  • ENSG00000185475
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
transcription factor binding site profile
0.66
cell type or tissue
0.64
disease perturbation
0.62
tissue sample
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.13   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.13   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.984466311
p_ni:  0.002209808
p_wrong:  0.013323881
Data Source:  BioPlex
TM4SF18
Tbio
Novelty:  0.16102348
p_int:  0.96532924
p_ni:  0.000578499
p_wrong:  0.034092261
Score:  0.404
Data Source:  BioPlex,STRINGDB
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.904537469
p_ni:  0.002238797
p_wrong:  0.093223734
Data Source:  BioPlex
LRRC8B
Tbio
Novelty:  0.16457267
p_int:  0.880061162
p_ni:  0.002588403
p_wrong:  0.117350435
Data Source:  BioPlex
PTGIR
Tclin
Family:  GPCR
Novelty:  0.0091906
p_int:  0.843238752
p_ni:  0.006990095
p_wrong:  0.149771153
Data Source:  BioPlex
TMX1
Tbio
Novelty:  0.03444237
p_int:  0.843238752
p_ni:  0.006990095
p_wrong:  0.149771153
Data Source:  BioPlex
TMEM107
Tbio
Novelty:  0.02571599
p_int:  0.831311634
p_ni:  0.004978426
p_wrong:  0.163709941
Score:  0.345
Data Source:  BioPlex,STRINGDB
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.807476398
p_ni:  0.008747403
p_wrong:  0.183776199
Score:  0.481
Data Source:  BioPlex,STRINGDB
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.807370825
p_ni:  0.001736809
p_wrong:  0.190892367
Data Source:  BioPlex
SLC39A8
Tbio
Family:  Transporter
Novelty:  0.00923197
p_int:  0.781680891
p_ni:  0.004648508
p_wrong:  0.213670601
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
62.3
blood protein measurement
1
1
1
45.4
fatty acid measurement
1
2
2
30.9
smoking status measurement
1
1
1
18
BMI-adjusted waist-hip ratio
2
1
2
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
62.3
blood protein measurement
1
45.4
fatty acid measurement
2
30.9
smoking status measurement
1
18
BMI-adjusted waist-hip ratio
2
12.1
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 179B
VGNC:975
451265
Macaque
transmembrane protein 179B
718518
Mouse
MGI:2444957
225895
Rat
RGD:1582850
690263
Dog
transmembrane protein 179B
VGNC:47505
612191
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 179B
Macaque
transmembrane protein 179B
Mouse
Rat
Dog
transmembrane protein 179B
Publication Statistics
PubMed Score 0.13
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title