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Tbio
GALNT5
Polypeptide N-acetylgalactosaminyltransferase 5

Protein Summary
Description
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity). The protein encoded by this gene is a membrane-bound polypeptide N-acetylgalactosaminyltransferase that is found in the Golgi. The encoded protein catalyzes the first step in the mucin-type O-glycosylation of Golgi proteins, transfering an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259056
  • ENSP00000259056
  • ENSG00000136542

Symbol
  • GALNACT5
  • GALNAC-T5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.56
cell type or tissue
0.55
tissue sample
0.48
cell line
0.47
tissue
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.8   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.8   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (41)
1 – 10 of 41
GIF
Tbio
Novelty:  0.00508343
p_int:  0.845733285
p_ni:  0.154266715
Score:  0.692
Data Source:  BioPlex,STRINGDB
C1GALT1
Tbio
Family:  Enzyme
Novelty:  0.01191596
Score:  0.966
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.935
Data Source:  STRINGDB
MUC1
Tchem
Novelty:  0.00024203
Score:  0.934
Data Source:  STRINGDB
MUC20
Tbio
Novelty:  0.04645313
Score:  0.923
Data Source:  STRINGDB
MUC6
Tbio
Novelty:  0.00304872
Score:  0.923
Data Source:  STRINGDB
MUC4
Tbio
Novelty:  0.00193208
Score:  0.916
Data Source:  STRINGDB
MUC5B
Tbio
Novelty:  0.000832
Score:  0.916
Data Source:  STRINGDB
MUC16
Tbio
Novelty:  0.00444587
Score:  0.911
Data Source:  STRINGDB
MUC7
Tbio
Novelty:  0.00750654
Score:  0.91
Data Source:  STRINGDB
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 5
VGNC:10822
470563
Macaque
polypeptide N-acetylgalactosaminyltransferase 5
697430
Mouse
MGI:2179403
241391
Rat
RGD:620361
83627
Dog
polypeptide N-acetylgalactosaminyltransferase 5
VGNC:53096
488359
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 5
Macaque
polypeptide N-acetylgalactosaminyltransferase 5
Mouse
Rat
Dog
polypeptide N-acetylgalactosaminyltransferase 5
Publication Statistics
PubMed Score 5.80
PubMed score by year
PubTator Score 3.12
PubTator score by year