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Tdark
ZNF467
Zinc finger protein 467

Protein Summary
Description
Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity). The protein encoded by this gene is a zinc finger protein whose function has not yet been elucidated in humans. However, the mouse ortholog of this protein enhances adipocyte differentiation and suppresses osteoblast differentiation in bone marrow. The mouse protein also is a transcription factor for several genes and can help recruit histone deacetylase complexes. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302017
  • ENSP00000304769
  • ENSG00000181444

Symbol
  • EZI
  • Zfp467
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.7
disease perturbation
0.68
tissue sample
0.66
transcription factor perturbation
0.61
cell type or tissue
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (10)
1 – 10 of 10
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.919
Data Source:  STRINGDB
TTYH3
Tbio
Family:  IC
Novelty:  0.21747247
Score:  0.653
Data Source:  STRINGDB
ZNF638
Tbio
Novelty:  0.13248064
Score:  0.54
Data Source:  STRINGDB
ZNF395
Tbio
Novelty:  0.07158931
Score:  0.525
Data Source:  STRINGDB
SYMPK
Tbio
Novelty:  0.01773552
Score:  0.496
Data Source:  STRINGDB
IPO7
Tbio
Novelty:  0.01319011
Score:  0.475
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.469
Data Source:  STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.463
Data Source:  STRINGDB
STAT4
Tchem
Family:  TF
Novelty:  0.00251747
Score:  0.447
Data Source:  STRINGDB
TCF7L1
Tbio
Family:  TF
Novelty:  0.03807371
Score:  0.408
Data Source:  STRINGDB
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Transcriptional regulation of white adipocyte differentiation
Name
Explore in Pharos
Explore in Source
Developmental Biology
Transcriptional regulation of white adipocyte differentiation
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
2
1
2
81.2
platelet crit
1
1
1
63.1
pulse pressure measurement
1
1
1
49.5
platelet count
1
1
1
31.4
systolic blood pressure change measurement
1
1
0
73.7
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
2
81.2
platelet crit
1
63.1
pulse pressure measurement
1
49.5
platelet count
1
31.4
systolic blood pressure change measurement
0
73.7
21.5
Find similar targets by:
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 467
VGNC:4578
100609200
Mouse
MGI:1916160
68910
Rat
RGD:1561603
500110
Dog
zinc finger protein 467
VGNC:48735
482787
Cow
zinc finger protein 467
VGNC:37281
527301
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 467
Mouse
Rat
Dog
zinc finger protein 467
Cow
zinc finger protein 467
Publication Statistics
PubMed Score 9.55
PubMed score by year
PubTator Score 1.11
PubTator score by year