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Tbio
MRPL10
39S ribosomal protein L10, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290208
  • ENSP00000290208
  • ENSG00000159111
  • ENST00000351111
  • ENSP00000324100
  • ENST00000414011
  • ENSP00000395870

Symbol
  • MRPL8
  • RPML8
  • L10MT
  • MRPL8
  • RPML8
  • MRP-L8
  • MRP-L10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
hub protein
0.67
transcription factor binding site profile
0.67
histone modification site profile
0.63
tissue sample
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.23   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.23   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.982
Data Source:  BioPlex,STRINGDB
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.999998326
p_ni:  0.000001674
Score:  0.981
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.999996204
p_ni:  0.000003796
Score:  0.992
Data Source:  BioPlex,STRINGDB
MRPL50
Tdark
Novelty:  0.88879319
p_int:  0.999946993
p_ni:  0.000053007
Score:  0.978
Data Source:  BioPlex,STRINGDB
MRPL42
Tbio
Novelty:  0.48241447
p_int:  0.999945325
p_ni:  0.000054675
Score:  0.967
Data Source:  BioPlex,STRINGDB
MRPL47
Tbio
Novelty:  0.05648009
p_int:  0.999943956
p_ni:  0.000056044
Score:  0.979
Data Source:  BioPlex,STRINGDB
MRPL45
Tdark
Novelty:  0.42464896
p_int:  0.999925126
p_ni:  0.000074874
Score:  0.98
Data Source:  BioPlex,STRINGDB
MRPL2
Tdark
Novelty:  1.01237797
p_int:  0.999902118
p_ni:  0.000097882
Score:  0.979
Data Source:  BioPlex,STRINGDB
MRPL51
Tdark
Novelty:  0.24304433
p_int:  0.999728915
p_ni:  0.000271079
p_wrong:  6e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
MRPL55
Tdark
Novelty:  0.55956177
p_int:  0.999720799
p_ni:  0.0002792
Score:  0.993
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
3
0
1.1
93.5
pulse pressure measurement
1
1
1
80.1
serum non-albumin protein measurement
1
2
2
73.2
autoimmune thyroid disease
1
1
0
1.1
64
3
2
0
1.1
55.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
93.5
pulse pressure measurement
1
80.1
serum non-albumin protein measurement
2
73.2
autoimmune thyroid disease
0
1.1
64
0
1.1
55.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L10
VGNC:9443
749267
Macaque
mitochondrial ribosomal protein L10
695136
Mouse
MGI:1333801
107732
Rat
RGD:1588626
691075
Dog
mitochondrial ribosomal protein L10
VGNC:43376
608696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L10
Macaque
mitochondrial ribosomal protein L10
Mouse
Rat
Dog
mitochondrial ribosomal protein L10
Publication Statistics
PubMed Score 3.23
PubMed score by year
PubTator Score 3.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title