TMED4
Transmembrane emp24 domain-containing protein 4
Protein Summary
Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).
- ENST00000457408
- ENSP00000404042
- ENSG00000158604
- ENST00000481238
- ENSP00000417443
- ERS25
- HNLF
- ERS25
- p24a3
- GMP25iso
- p24alpha3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.91 | ||
disease perturbation | 0.9 | ||
histone modification site profile | 0.9 | ||
transcription factor perturbation | 0.8 | ||
cell type or tissue | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.97 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 132 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.97 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 132 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0