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Tbio
VPS13B
Vacuolar protein sorting-associated protein 13B

Protein Summary
Description
May be involved in protein sorting in post Golgi membrane traffic. This gene encodes a potential transmembrane protein that may function in vesicle-mediated transport and sorting of proteins within the cell. This protein may play a role in the development and the function of the eye, hematological system, and central nervous system. Mutations in this gene have been associated with Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355155
  • ENSP00000347281
  • ENSG00000132549
  • ENST00000357162
  • ENSP00000349685
  • ENST00000358544
  • ENSP00000351346
  • ENST00000441350
  • ENSP00000398472
  • ENST00000496144
  • ENSP00000430900

Symbol
  • CHS1
  • COH1
  • KIAA0532
  • CHS1
  • COH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
virus perturbation
0.92
transcription factor binding site profile
0.86
cell type or tissue
0.75
trait
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.52   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.52   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0