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Tbio
CLNK
Cytokine-dependent hematopoietic cell linker

Protein Classes
Protein Summary
Description
Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT (By similarity). MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226951
  • ENSP00000226951
  • ENSG00000109684
  • ENST00000507719
  • ENSP00000427208

Symbol
  • MIST
  • MIST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
cell line
0.56
cell type or tissue
0.53
disease
0.52
PubMedID
0.5


Related Tools
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GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.61   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.61   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
2
93.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
93.8
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytokine dependent hematopoietic cell linker
VGNC:6661
465224
Macaque
cytokine dependent hematopoietic cell linker
713238
Mouse
MGI:1351468
27278
Dog
cytokine dependent hematopoietic cell linker
VGNC:39352
488823
Horse
cytokine dependent hematopoietic cell linker
VGNC:16625
100069539
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytokine dependent hematopoietic cell linker
Macaque
cytokine dependent hematopoietic cell linker
Mouse
Dog
cytokine dependent hematopoietic cell linker
Horse
cytokine dependent hematopoietic cell linker
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (29)
1 – 10 of 29
LAT
Tbio
Novelty: 0.00738419
Score: 0.724
Data Source: STRINGDB
FCER1A
Tbio
Novelty: 0.00362182
Score: 0.628
Data Source: STRINGDB
LYN
Tclin
Family: Kinase
Novelty: 0.00097393
Score: 0.609
Data Source: STRINGDB
SPINK5
Tbio
Family: Enzyme
Novelty: 0.00451563
Score: 0.577
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.558
Data Source: STRINGDB
SLITRK1
Tbio
Novelty: 0.0132455
Score: 0.558
Data Source: STRINGDB
PECAM1
Tbio
Novelty: 0.00013373
Score: 0.523
Data Source: STRINGDB
SNX22
Tdark
Novelty: 0.26806147
Score: 0.522
Data Source: STRINGDB
SOCS6
Tbio
Novelty: 0.00993375
Score: 0.515
Data Source: STRINGDB
SOCS4
Tbio
Novelty: 0.01633743
Score: 0.515
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.61

PubMed score by year
PubTator Score  41.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer