Tdark MRPL55 39S ribosomal protein L55, mitochondrial

Protein Summary

Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q7Z7F7
• Q5TBY3
• Q5TBY6
• Q6UWI8
• L55mt

Gene Name

• MRPL55

Ensembl ID

• ENST00000295008
• ENSP00000295008
• ENSG00000162910
• ENST00000336300
• ENSP00000337361
• ENST00000336520
• ENSP00000337342
• ENST00000348259
• ENSP00000338189
• ENST00000366733
• ENSP00000355694
• ENST00000366734
• ENSP00000355695
• ENST00000366735
• ENSP00000355696
• ENST00000366736
• ENSP00000355697
• ENST00000366738
• ENSP00000355699
• ENST00000366739
• ENSP00000355700
• ENST00000366740
• ENSP00000355701
• ENST00000366741
• ENSP00000355702
• ENST00000366742
• ENSP00000355703
• ENST00000366744
• ENSP00000355705
• ENST00000366746
• ENSP00000355707
• ENST00000366747
• ENSP00000355708
• ENST00000391867
• ENSP00000375740
• ENST00000430433
• ENSP00000403614

Symbol

• L55nt
• MRP-L55
• AAVG5835
• PRO19675

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
transcription factor binding site profile	0.72
cell line	0.61
cellular component	0.61
virus perturbation	0.55

Related Tools

GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.36   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.36   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mitochondrial ribosomal protein L55	VGNC:11543	739279
Macaque	mitochondrial ribosomal protein L55		695962
Mouse	mitochondrial ribosomal protein L55	MGI:1914462	67212
Rat	mitochondrial ribosomal protein L55	RGD:1308161	287356
Dog	mitochondrial ribosomal protein L55	VGNC:54787	607317

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitochondrial ribosomal protein L55
Macaque	mitochondrial ribosomal protein L55
Mouse	mitochondrial ribosomal protein L55
Rat	mitochondrial ribosomal protein L55
Dog	mitochondrial ribosomal protein L55

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7Z7F7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (6)

Reactome (6)

Metabolism of proteins (R-HSA-392499)

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Items per page:

5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Mitochondrial translation	96 targets	R-HSA-5368287
Reactome	Mitochondrial translation elongation	90 targets	R-HSA-5389840
Reactome	Mitochondrial translation initiation	90 targets	R-HSA-5368286
Reactome	Mitochondrial translation termination	90 targets	R-HSA-5419276

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Mitochondrial translation	96 targets	R-HSA-5368287
Mitochondrial translation elongation	90 targets	R-HSA-5389840
Mitochondrial translation initiation	90 targets	R-HSA-5368286
Mitochondrial translation termination	90 targets	R-HSA-5419276

Gene Ontology Terms (7)

Functions (1)

Components (3)

Processes (3)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
structural constituent of ribosome	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Protein-Protein Interactions (145)

Explore Interacting Targets

1 – 10 of 145

• See Interactions on String-DB

MRPL46

Tdark

Novelty: 0.6199259

p_int: 0.999953095

p_ni: 0.000046904

Score: 0.991

Data Source: BioPlex,STRINGDB

MRPS30

Tbio

Novelty: 0.08115544

p_int: 0.999927737

p_ni: 0.000072263

Score: 0.984

Data Source: BioPlex,STRINGDB

MRPL50

Tdark

Novelty: 0.88879319

p_int: 0.999854615

p_ni: 0.000145385

Score: 0.979

Data Source: BioPlex,STRINGDB

MRPL30

Tdark

Novelty: 1.03623556

p_int: 0.999849424

p_ni: 0.000150576

Score: 0.954

Data Source: BioPlex,STRINGDB

MRPL13

Tbio

Novelty: 0.04173503

p_int: 0.999844967

p_ni: 0.000155033

Score: 0.992

Data Source: BioPlex,STRINGDB

MRPL10

Tbio

Novelty: 0.27087019

p_int: 0.999720799

p_ni: 0.0002792

Score: 0.993

Data Source: BioPlex,STRINGDB

MRPL18

Tbio

Novelty: 0.73438796

p_int: 0.9996375

p_ni: 0.0003625

Score: 0.985

Data Source: BioPlex,STRINGDB

MRPL52

Tdark

Novelty: 0.72949349

p_int: 0.999369282

p_ni: 0.000630718

Score: 0.994

Data Source: BioPlex,STRINGDB

RPL37

Tbio

Novelty: 0.03935854

p_int: 0.999323421

p_ni: 0.000676579

Data Source: BioPlex

MRPL47

Tbio

Novelty: 0.05648009

p_int: 0.999145525

p_ni: 0.000848848

p_wrong: 0.000005627

Score: 0.987

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  1.36

PubMed score by year

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PubTator Score  0.69

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Complete proteome
Mitochondrion
Phosphoprotein
Polymorphism
Reference proteome
Ribonucleoprotein
Ribosomal protein
Transit peptide