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Tdark
MRPL55
39S ribosomal protein L55, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295008
  • ENSP00000295008
  • ENSG00000162910
  • ENST00000336300
  • ENSP00000337361
  • ENST00000336520
  • ENSP00000337342
  • ENST00000348259
  • ENSP00000338189
  • ENST00000366733
  • ENSP00000355694
  • ENST00000366734
  • ENSP00000355695
  • ENST00000366735
  • ENSP00000355696
  • ENST00000366736
  • ENSP00000355697
  • ENST00000366738
  • ENSP00000355699
  • ENST00000366739
  • ENSP00000355700
  • ENST00000366740
  • ENSP00000355701
  • ENST00000366741
  • ENSP00000355702
  • ENST00000366742
  • ENSP00000355703
  • ENST00000366744
  • ENSP00000355705
  • ENST00000366746
  • ENSP00000355707
  • ENST00000366747
  • ENSP00000355708
  • ENST00000391867
  • ENSP00000375740
  • ENST00000430433
  • ENSP00000403614

Symbol
  • L55nt
  • MRP-L55
  • AAVG5835
  • PRO19675
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor binding site profile
0.72
cell line
0.61
cellular component
0.61
virus perturbation
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.36   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.36   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (145)
MRPL46
Tdark
Novelty:  0.6199259
p_int:  0.999953095
p_ni:  0.000046904
Score:  0.991
Data Source:  BioPlex,STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.999927737
p_ni:  0.000072263
Score:  0.984
Data Source:  BioPlex,STRINGDB
MRPL50
Tdark
Novelty:  0.88879319
p_int:  0.999854615
p_ni:  0.000145385
Score:  0.979
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.999849424
p_ni:  0.000150576
Score:  0.954
Data Source:  BioPlex,STRINGDB
MRPL13
Tbio
Novelty:  0.04173503
p_int:  0.999844967
p_ni:  0.000155033
Score:  0.992
Data Source:  BioPlex,STRINGDB
MRPL10
Tbio
Novelty:  0.27087019
p_int:  0.999720799
p_ni:  0.0002792
Score:  0.993
Data Source:  BioPlex,STRINGDB
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.9996375
p_ni:  0.0003625
Score:  0.985
Data Source:  BioPlex,STRINGDB
MRPL52
Tdark
Novelty:  0.72949349
p_int:  0.999369282
p_ni:  0.000630718
Score:  0.994
Data Source:  BioPlex,STRINGDB
RPL37
Tbio
Novelty:  0.03935854
p_int:  0.999323421
p_ni:  0.000676579
Data Source:  BioPlex
MRPL47
Tbio
Novelty:  0.05648009
p_int:  0.999145525
p_ni:  0.000848848
p_wrong:  0.000005627
Score:  0.987
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
2
1
0
1.2
46.1
birth weight
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
0
1.2
46.1
birth weight
1
33.1
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L55
VGNC:11543
739279
Macaque
mitochondrial ribosomal protein L55
695962
Mouse
MGI:1914462
67212
Rat
RGD:1308161
287356
Dog
mitochondrial ribosomal protein L55
VGNC:54787
607317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L55
Macaque
mitochondrial ribosomal protein L55
Mouse
Rat
Dog
mitochondrial ribosomal protein L55
Publication Statistics
PubMed Score 1.36
PubMed score by year
PubTator Score 0.69
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title