Tdark MRPL55 39S ribosomal protein L55, mitochondrial

Protein Summary

Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q7Z7F7
• Q5TBY3
• Q5TBY6
• Q6UWI8
• L55mt

Gene Name

• MRPL55

Ensembl ID

• ENST00000295008
• ENSP00000295008
• ENSG00000162910
• ENST00000336300
• ENSP00000337361
• ENST00000336520
• ENSP00000337342
• ENST00000348259
• ENSP00000338189
• ENST00000366733
• ENSP00000355694
• ENST00000366734
• ENSP00000355695
• ENST00000366735
• ENSP00000355696
• ENST00000366736
• ENSP00000355697
• ENST00000366738
• ENSP00000355699
• ENST00000366739
• ENSP00000355700
• ENST00000366740
• ENSP00000355701
• ENST00000366741
• ENSP00000355702
• ENST00000366742
• ENSP00000355703
• ENST00000366744
• ENSP00000355705
• ENST00000366746
• ENSP00000355707
• ENST00000366747
• ENSP00000355708
• ENST00000391867
• ENSP00000375740
• ENST00000430433
• ENSP00000403614

Symbol

• L55nt
• MRP-L55
• AAVG5835
• PRO19675

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
transcription factor binding site profile	0.72
cell line	0.61
cellular component	0.61
virus perturbation	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.36   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.36   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (145)

Explore Interacting Targets

1 – 10 of 145

• See Interactions on String-DB

MRPL46

Tdark

Novelty:  0.6199259

p_int:  0.999953095

p_ni:  0.000046904

Score:  0.991

Data Source:  BioPlex,STRINGDB

MRPS30

Tbio

Novelty:  0.08115544

p_int:  0.999927737

p_ni:  0.000072263

Score:  0.984

Data Source:  BioPlex,STRINGDB

MRPL50

Tdark

Novelty:  0.88879319

p_int:  0.999854615

p_ni:  0.000145385

Score:  0.979

Data Source:  BioPlex,STRINGDB

MRPL30

Tdark

Novelty:  1.03623556

p_int:  0.999849424

p_ni:  0.000150576

Score:  0.954

Data Source:  BioPlex,STRINGDB

MRPL13

Tbio

Novelty:  0.04173503

p_int:  0.999844967

p_ni:  0.000155033

Score:  0.992

Data Source:  BioPlex,STRINGDB

MRPL10

Tbio

Novelty:  0.27087019

p_int:  0.999720799

p_ni:  0.0002792

Score:  0.993

Data Source:  BioPlex,STRINGDB

MRPL18

Tbio

Novelty:  0.73438796

p_int:  0.9996375

p_ni:  0.0003625

Score:  0.985

Data Source:  BioPlex,STRINGDB

MRPL52

Tdark

Novelty:  0.72949349

p_int:  0.999369282

p_ni:  0.000630718

Score:  0.994

Data Source:  BioPlex,STRINGDB

RPL37

Tbio

Novelty:  0.03935854

p_int:  0.999323421

p_ni:  0.000676579

Data Source:  BioPlex

MRPL47

Tbio

Novelty:  0.05648009

p_int:  0.999145525

p_ni:  0.000848848

p_wrong:  0.000005627

Score:  0.987

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (6)

Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Mitochondrial translation	96 targets	R-HSA-5368287
Reactome	Mitochondrial translation elongation	90 targets	R-HSA-5389840
Reactome	Mitochondrial translation initiation	90 targets	R-HSA-5368286
Reactome	Mitochondrial translation termination	90 targets	R-HSA-5419276

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Mitochondrial translation	96 targets	R-HSA-5368287
Mitochondrial translation elongation	90 targets	R-HSA-5389840
Mitochondrial translation initiation	90 targets	R-HSA-5368286
Mitochondrial translation termination	90 targets	R-HSA-5419276

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (3)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
structural constituent of ribosome	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
adolescent idiopathic scoliosis	EFO_0005423	2	1	0	1.2	46.1
birth weight	EFO_0004344	1	1	1		33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
adolescent idiopathic scoliosis	EFO_0005423	0	1.2	46.1
birth weight	EFO_0004344	1		33.1

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Mitochondrion
Phosphoprotein
Polymorphism
Reference proteome
Ribonucleoprotein
Ribosomal protein
Transit peptide

GWAS Trait Find Similar Targets

No Header	No Header
adolescent idiopathic scoliosis
birth weight

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mitochondrial ribosomal protein L55	VGNC:11543	739279
Macaque	mitochondrial ribosomal protein L55		695962
Mouse	mitochondrial ribosomal protein L55	MGI:1914462	67212
Rat	mitochondrial ribosomal protein L55	RGD:1308161	287356
Dog	mitochondrial ribosomal protein L55	VGNC:54787	607317

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitochondrial ribosomal protein L55
Macaque	mitochondrial ribosomal protein L55
Mouse	mitochondrial ribosomal protein L55
Rat	mitochondrial ribosomal protein L55
Dog	mitochondrial ribosomal protein L55

Publication Statistics

PubMed Score 1.36

PubMed score by year

Reset Zoom

PubTator Score 0.69

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (15)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title