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Tdark
KHDC4
KH homology domain-containing protein 4

Protein Summary
Description
RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368319
  • ENSP00000357302
  • ENSG00000132680
  • ENST00000368320
  • ENSP00000357303
  • ENST00000368321
  • ENSP00000357304

Symbol
  • BLOM7
  • KIAA0907
  • SNORA80EHG
  • BLOM7
  • KIAA0907
  • SNORA80EHG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.19   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.19   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (37)
1 – 10 of 37
STARD7
Tbio
Novelty:  0.04511594
p_int:  0.999970087
p_ni:  3e-8
p_wrong:  0.000029883
Score:  0.381
Data Source:  BioPlex,STRINGDB
SERPINB5
Tbio
Novelty:  0.00192585
p_int:  0.984357892
p_ni:  0.015642108
Data Source:  BioPlex
CALML5
Tbio
Novelty:  0.03240679
p_int:  0.980622503
p_ni:  0.019377497
Data Source:  BioPlex
IGHG2
Tclin
p_int:  0.960500998
p_ni:  0.039498999
p_wrong:  3e-9
Data Source:  BioPlex
IGKC
Tdark
p_int:  0.953991111
p_ni:  0.046008889
Data Source:  BioPlex
SERPINB2
Tbio
Novelty:  0.00204345
p_int:  0.953076209
p_ni:  0.043548646
p_wrong:  0.003375146
Data Source:  BioPlex
TYMP
Tclin
Family:  Enzyme
Novelty:  0.0015906
p_int:  0.9302378
p_ni:  0.069762187
p_wrong:  1.3e-8
Data Source:  BioPlex
S100A7
Tbio
Novelty:  0.00434262
p_int:  0.903320077
p_ni:  0.096679923
Score:  0.163
Data Source:  BioPlex,STRINGDB
TRIM29
Tbio
Novelty:  0.02572789
p_int:  0.892719583
p_ni:  0.107280364
p_wrong:  5.4e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.879712286
p_ni:  0.120287664
p_wrong:  5e-8
Data Source:  BioPlex
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
3
3
68.3
sex hormone-binding globulin measurement
2
1
2
61
birth weight
1
1
1
51.7
1
1
0
1.1
46.5
testosterone measurement
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
68.3
sex hormone-binding globulin measurement
2
61
birth weight
1
51.7
0
1.1
46.5
testosterone measurement
1
42.3
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
KH domain containing 4, pre-mRNA splicing factor
718005
Mouse
MGI:1921450
74200
Rat
RGD:1565775
361980
Dog
KH domain containing 4, pre-mRNA splicing factor
VGNC:42354
612936
Horse
KH domain containing 4, pre-mRNA splicing factor
VGNC:19368
100057540
Species
Name
OMA
EggNOG
Inparanoid
Macaque
KH domain containing 4, pre-mRNA splicing factor
Mouse
Rat
Dog
KH domain containing 4, pre-mRNA splicing factor
Horse
KH domain containing 4, pre-mRNA splicing factor
Publication Statistics
PubMed Score 3.19
PubMed score by year
PubTator Score 1.83
PubTator score by year