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Tbio
UBE2Q1
Ubiquitin-conjugating enzyme E2 Q1

Protein Summary
Description
Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity). The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292211
  • ENSP00000292211
  • ENSG00000160714

Symbol
  • NICE5
  • UBE2Q
  • GTAP
  • NICE5
  • UBE2Q
  • NICE-5
  • PRO3094
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
virus perturbation
1
transcription factor binding site profile
0.88
molecular function
0.81
microRNA
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.63   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.63   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
7
12
14
99.6
interleukin 6 receptor subunit alpha measurement
2
2
2
96.3
sex hormone-binding globulin measurement
6
3
6
96
interleukin-6 measurement
2
3
3
94
fibrinogen measurement
3
2
2
5.3
89.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
14
99.6
interleukin 6 receptor subunit alpha measurement
2
96.3
sex hormone-binding globulin measurement
6
96
interleukin-6 measurement
3
94
fibrinogen measurement
2
5.3
89.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 Q1
VGNC:8120
740158
Macaque
ubiquitin conjugating enzyme E2 Q1
718733
Mouse
MGI:1917343
70093
Rat
RGD:1305305
295252
Dog
ubiquitin conjugating enzyme E2 Q1
VGNC:48061
100688676
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 Q1
Macaque
ubiquitin conjugating enzyme E2 Q1
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 Q1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7Z7E8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (286)
1 – 10 of 286
C1QTNF2
Tbio
Novelty:  0.18607978
p_int:  0.999999943
p_ni:  5.7e-8
Score:  0.191
Data Source:  BioPlex,STRINGDB
UBE2Q2
Tbio
Novelty:  0.12491522
p_int:  0.999999917
p_ni:  4e-9
p_wrong:  7.9e-8
Score:  0.901
Data Source:  BioPlex,STRINGDB
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.999458883
p_ni:  0.000541117
Data Source:  BioPlex
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.997892458
p_ni:  0.002107345
p_wrong:  1.97e-7
Data Source:  BioPlex
MFSD11
Tdark
Novelty:  0.13167358
p_int:  0.996055704
p_ni:  0.003944172
p_wrong:  1.25e-7
Score:  0.325
Data Source:  BioPlex,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.995856005
p_ni:  0.00365395
p_wrong:  0.000490045
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.994750891
p_ni:  0.004867634
p_wrong:  0.000381475
Data Source:  BioPlex
GPR161
Tbio
Family:  GPCR
Novelty:  0.00235739
p_int:  0.991356663
p_ni:  0.005607777
p_wrong:  0.00303556
Score:  0.169
Data Source:  BioPlex,STRINGDB
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  0.98961133
p_ni:  0.008063791
p_wrong:  0.002324878
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.986100549
p_ni:  0.013635882
p_wrong:  0.000263569
Data Source:  BioPlex
Publication Statistics
PubMed Score  17.63

PubMed score by year
PubTator Score  11.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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