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Tbio
TAF8
Transcription initiation factor TFIID subunit 8

Protein Summary
Description
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFII ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372977
  • ENSP00000362068
  • ENSG00000137413
  • ENST00000372982
  • ENSP00000362073
  • ENST00000456846
  • ENSP00000411900
  • ENST00000494547
  • ENSP00000417867

Symbol
  • TAFII43
  • TBN
  • II
  • TAF
  • TBN
  • TAFII43
  • TAFII-43
  • TAF(II)43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
hub protein
0.71
kinase perturbation
0.66
transcription factor
0.64
pathway
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.01   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.01   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
86.6
mosaic loss of chromosome Y measurement
2
1
2
77.1
monocyte count
1
1
1
51.3
lymphocyte percentage of leukocytes
1
1
1
32.2
neutrophil percentage of leukocytes
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
86.6
mosaic loss of chromosome Y measurement
2
77.1
monocyte count
1
51.3
lymphocyte percentage of leukocytes
1
32.2
neutrophil percentage of leukocytes
1
7.8
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (143)
1 – 10 of 143
TAF3
Tbio
Family: Epigenetic
Novelty: 0.05517331
p_int: 0.999999995
p_ni: 5e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
TAF2
Tbio
Novelty: 0.0397428
p_int: 0.999999988
p_ni: 1.2e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
TAF1
Tchem
Family: Kinase
Novelty: 0.00555929
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
TAF4B
Tbio
Novelty: 0.70515005
p_int: 0.999999955
p_ni: 4.5e-8
Score: 0.977
Data Source: BioPlex,STRINGDB
TAF9B
Tbio
Novelty: 0.0285313
p_int: 0.999999941
p_ni: 5.9e-8
Score: 0.99
Data Source: BioPlex,STRINGDB
TAF5
Tbio
Novelty: 0.05443551
p_int: 0.999999908
p_ni: 9.2e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
TAF6
Tbio
Novelty: 0.04357176
p_int: 0.999999825
p_ni: 1.75e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
TAF11
Tbio
Novelty: 0.10299251
p_int: 0.99999966
p_ni: 9e-8
p_wrong: 2.5e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
TAF4
Tbio
Novelty: 0.02101584
p_int: 0.9999994
p_ni: 6e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
TAF7
Tbio
Novelty: 0.05316615
p_int: 0.999999159
p_ni: 8.41e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  95.01

PubMed score by year
PubTator Score  199.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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