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Tbio
DEFB128
Beta-defensin 128

Protein Summary
Description
Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334391
  • ENSP00000335382
  • ENSG00000185982

Symbol
  • DEFB28
  • DEFB28
  • hBD-28
  • DEFB-28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.42
protein complex
0.4
biological term
0.33
pathway
0.32
tissue sample
0.28


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.04   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.04   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
DEFB125
Tdark
Novelty:  0.69005738
Score:  0.983
Data Source:  STRINGDB
DEFB135
Tdark
Novelty:  2.04107063
Score:  0.98
Data Source:  STRINGDB
DEFB124
Tbio
Novelty:  1.65330827
Score:  0.977
Data Source:  STRINGDB
DEFB126
Tbio
Novelty:  0.05538355
Score:  0.967
Data Source:  STRINGDB
DEFB132
Tdark
Novelty:  0.43147041
Score:  0.965
Data Source:  STRINGDB
DEFB134
Tdark
Novelty:  0.94544485
Score:  0.961
Data Source:  STRINGDB
DEFB129
Tdark
Novelty:  0.26809608
Score:  0.958
Data Source:  STRINGDB
DEFB114
Tbio
Novelty:  0.22206668
Score:  0.956
Data Source:  STRINGDB
DEFB110
Tdark
Novelty:  0.49548192
Score:  0.954
Data Source:  STRINGDB
DEFB119
Tbio
Novelty:  0.36154966
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2442320
319579
Rat
RGD:1565177
641641
Dog
defensin beta 128
VGNC:39881
100683301
Horse
defensin beta 128
VGNC:17115
106782419
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
defensin beta 128
Horse
defensin beta 128
Publication Statistics
PubMed Score 3.04
PubMed score by year
PubTator Score 3.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title