You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
DEFB132
Beta-defensin 132

Protein Summary
Description
Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. This protein binds spermatozoa and has antimicrobial activity against E. coli. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382376
  • ENSP00000371813
  • ENSG00000186458

Symbol
  • DEFB32
  • BD-32
  • DEFB32
  • HEL-75
  • UNQ827
  • DEFB-32
  • KFLL827
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.49
microRNA
0.47
tissue
0.39
tissue sample
0.35
biological term
0.33


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.2   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.2   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin beta 132
VGNC:6095
745492
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin beta 132
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z7B7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (31)
1 – 10 of 31
DEFB127
Tbio
Novelty:  0.18126756
Score:  0.989
Data Source:  STRINGDB
DEFB118
Tbio
Novelty:  0.14992977
Score:  0.979
Data Source:  STRINGDB
DEFB126
Tbio
Novelty:  0.05538355
Score:  0.972
Data Source:  STRINGDB
DEFB125
Tdark
Novelty:  0.69005738
Score:  0.965
Data Source:  STRINGDB
DEFB128
Tbio
Novelty:  0.30093411
Score:  0.965
Data Source:  STRINGDB
DEFB119
Tbio
Novelty:  0.36154966
Score:  0.961
Data Source:  STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
Score:  0.961
Data Source:  STRINGDB
DEFB129
Tdark
Novelty:  0.26809608
Score:  0.958
Data Source:  STRINGDB
DEFA4
Tbio
Novelty:  0.04566082
Score:  0.932
Data Source:  STRINGDB
DEFB133
Tdark
Novelty:  8.07692308
Score:  0.9
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.20

PubMed score by year
PubTator Score  1.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer