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Tbio
KRT77
Keratin, type II cytoskeletal 1b

Protein Summary
Description
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341809
  • ENSP00000342710
  • ENSG00000189182

Symbol
  • KRT1B
  • K1B
  • KRT1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
interacting protein
0.96
protein domain
0.58
cellular component
0.57
cell line
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.45   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 554   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.45   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 554   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 77
VGNC:8455
466994
Mouse
MGI:3588209
406220
Rat
RGD:1302968
406226
Horse
keratin 77
VGNC:19539
100061792
Cow
keratin 77
VGNC:50406
100336698
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 77
Mouse
Rat
Horse
keratin 77
Cow
keratin 77
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z794-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (78)
1 – 10 of 78
KRT10
Tbio
Novelty: 0.00166073
Score: 0.996
Data Source: STRINGDB
KRT1
Tbio
Novelty: 0.00278467
Score: 0.995
Data Source: STRINGDB
KRT2
Tbio
Novelty: 0.01448252
Score: 0.994
Data Source: STRINGDB
KRT32
Tdark
Novelty: 1.12077627
Score: 0.933
Data Source: STRINGDB
KRT35
Tbio
Novelty: 0.01111091
Score: 0.932
Data Source: STRINGDB
KRT28
Tdark
Novelty: 0.48119283
Score: 0.931
Data Source: STRINGDB
KRT38
Tdark
Novelty: 0.25061021
Score: 0.931
Data Source: STRINGDB
KRT19
Tbio
Novelty: 0.00043162
Score: 0.93
Data Source: STRINGDB
KRT15
Tbio
Novelty: 0.00351898
Score: 0.93
Data Source: STRINGDB
KRT36
Tdark
Novelty: 0.50578568
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  74.45

PubMed score by year
PubTator Score  27.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer