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Tbio
HUWE1
E3 ubiquitin-protein ligase HUWE1

Protein Summary
Description
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4. This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262854
  • ENSP00000262854
  • ENSG00000086758
  • ENST00000342160
  • ENSP00000340648
  • ENST00000612484
  • ENSP00000479451

Symbol
  • KIAA0312
  • KIAA1578
  • UREB1
  • MULE
  • Ib772
  • LASU1
  • UREB1
  • HECTH9
  • URE-B1
  • ARF-BP1
  • HSPC272
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.97
disease perturbation
0.9
kinase perturbation
0.84
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.68   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.68   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (417)
UBC
Tbio
Novelty:  0.00204643
Score:  0.997
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.997
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.996
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.996
Data Source:  STRINGDB
PHAX
Tbio
Novelty:  0.04027466
Score:  0.976
Data Source:  STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.975
Data Source:  STRINGDB
UBA1
Tbio
Novelty:  0.00419724
Score:  0.97
Data Source:  STRINGDB
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
Score:  0.97
Data Source:  STRINGDB
TRIP12
Tbio
Family:  Enzyme
Novelty:  0.03433452
Score:  0.969
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
0.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
465650
Macaque
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
700136
Mouse
MGI:1926884
59026
Dog
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
VGNC:41841
480931
Horse
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
VGNC:18916
100060375
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Macaque
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Mouse
Dog
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Horse
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Publication Statistics
PubMed Score 100.68
PubMed score by year
PubTator Score 82.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title