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Tbio
HUWE1
E3 ubiquitin-protein ligase HUWE1

Protein Summary
Description
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4. This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262854
  • ENSP00000262854
  • ENSG00000086758
  • ENST00000342160
  • ENSP00000340648
  • ENST00000612484
  • ENSP00000479451

Symbol
  • KIAA0312
  • KIAA1578
  • UREB1
  • MULE
  • Ib772
  • LASU1
  • UREB1
  • HECTH9
  • URE-B1
  • ARF-BP1
  • HSPC272
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.97
disease perturbation
0.9
kinase perturbation
0.84
virus perturbation
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.43   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.43   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
465650
Macaque
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
700136
Mouse
MGI:1926884
59026
Dog
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
VGNC:41841
480931
Horse
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
VGNC:18916
100060375
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Macaque
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Mouse
Dog
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Horse
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Protein Structure (8 Structures, 16 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Innate Immune System
Gene Ontology Terms (22)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (417)
1 – 10 of 417
UBC
Tbio
Novelty: 0.00204643
Score: 0.997
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.997
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.996
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.996
Data Source: STRINGDB
PHAX
Tbio
Novelty: 0.04027466
Score: 0.976
Data Source: STRINGDB
UBE2D2
Tbio
Novelty: 0.00603877
Score: 0.975
Data Source: STRINGDB
UBA1
Tbio
Novelty: 0.00419724
Score: 0.97
Data Source: STRINGDB
HERC2
Tbio
Family: Enzyme
Novelty: 0.06552683
Score: 0.97
Data Source: STRINGDB
TRIP12
Tbio
Family: Enzyme
Novelty: 0.03433452
Score: 0.969
Data Source: STRINGDB
UBE2D1
Tbio
Novelty: 0.00865867
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.43

PubMed score by year
PubTator Score  82.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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