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Tdark
PNPLA5
Patatin-like phospholipase domain-containing protein 5

Protein Summary
Description
Lipid hydrolase. This gene is a member of the patatin-like phospholipase family; its encoded protein has been shown to inhibit transacylation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216177
  • ENSP00000216177
  • ENSG00000100341
  • ENST00000381198
  • ENSP00000370595
  • ENST00000593866
  • ENSP00000471795
  • ENST00000597664
  • ENSP00000471069

Symbol
  • GS2L
  • GS2L
  • dJ388M5
  • dJ388M5.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
tissue
0.56
cell line
0.49
microRNA
0.43
transcription factor
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.5   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.5   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
UBA52
Tbio
Novelty:  0.01637744
p_int:  0.999981726
p_ni:  0.000018274
Score:  0.206
Data Source:  BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int:  0.999888633
p_ni:  0.000111168
p_wrong:  1.99e-7
Data Source:  BioPlex
STIP1
Tbio
Novelty:  0.00590952
p_int:  0.99379469
p_ni:  0.00620531
Score:  0.206
Data Source:  BioPlex,STRINGDB
CCT4
Tbio
Novelty:  0.01176123
p_int:  0.874280937
p_ni:  0.125719063
Score:  0.218
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.862196722
p_ni:  0.137803278
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.856027464
p_ni:  0.143972536
Data Source:  BioPlex
BAG3
Tbio
Novelty:  0.0042967
p_int:  0.825167416
p_ni:  0.174832584
Score:  0.195
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.790806836
p_ni:  0.209193164
Score:  0.2
Data Source:  BioPlex,STRINGDB
LDLRAP1
Tbio
Novelty:  0.0150723
Score:  0.73
Data Source:  STRINGDB
APOC3
Tclin
Novelty:  0.0009635
Score:  0.712
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Triglyceride catabolism
Reactome
Triglyceride metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Triglyceride catabolism
Triglyceride metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
5
4
8
37.7
98.8
serum alanine aminotransferase measurement
8
4
8
6
98.8
liver fibrosis measurement
3
3
9
96.7
7
3
1
1.8
95.8
hemoglobin measurement
4
3
5
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
8
37.7
98.8
serum alanine aminotransferase measurement
8
6
98.8
liver fibrosis measurement
9
96.7
1
1.8
95.8
hemoglobin measurement
5
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 5
VGNC:6021
470234
Macaque
patatin like phospholipase domain containing 5
712261
Mouse
MGI:1923022
75772
Rat
RGD:1307495
300108
Dog
patatin like phospholipase domain containing 5
VGNC:44755
481216
Species
Name
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 5
Macaque
patatin like phospholipase domain containing 5
Mouse
Rat
Dog
patatin like phospholipase domain containing 5
Publication Statistics
PubMed Score 4.50
PubMed score by year
PubTator Score 3.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title