Tbio PNPLA5 Patatin-like phospholipase domain-containing protein 5

Protein Summary

Description

Lipid hydrolase. This gene is a member of the patatin-like phospholipase family; its encoded protein has been shown to inhibit transacylation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q7Z6Z6
• B1AHL8
• B3KPR1
• Q6ZST0

Gene Name

• PNPLA5

Ensembl ID

• ENST00000216177
• ENSP00000216177
• ENSG00000100341
• ENST00000381198
• ENSP00000370595
• ENST00000593866
• ENSP00000471795
• ENST00000597664
• ENSP00000471069

Symbol

• GS2L
• GS2L
• dJ388M5
• dJ388M5.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.73
tissue	0.56
cell line	0.49
microRNA	0.43
transcription factor	0.42

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Patatin-like Phospholipase Domain-containing Protein 5

Protein / Hydrolase / Lipase / Phospholipase / Patatin-like Phospholipase Domain-containing Protein 5

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / Patatin-like Phospholipase Domain-containing Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.41   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 79   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.41   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0