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Tbio
TECPR1
Tectonin beta-propeller repeat-containing protein 1

Protein Summary
Description
Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000447648
  • ENSP00000404923
  • ENSG00000205356

Symbol
  • KIAA1358
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor perturbation
0.84
protein domain
0.73
cellular component
0.64
cell line
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.15   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.15   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
ATG5
Tbio
Novelty:  0.00081472
Score:  0.982
Data Source:  STRINGDB
WIPI2
Tbio
Novelty:  0.02685992
Score:  0.805
Data Source:  STRINGDB
ATG12
Tbio
Novelty:  0.00304298
Score:  0.725
Data Source:  STRINGDB
TYSND1
Tbio
Family:  Enzyme
Novelty:  0.16036122
Score:  0.652
Data Source:  STRINGDB
TRAPPC12
Tbio
Novelty:  0.09847363
Score:  0.584
Data Source:  STRINGDB
GPS1
Tbio
Novelty:  0.01433636
Score:  0.571
Data Source:  STRINGDB
DYSF
Tbio
Novelty:  0.00248634
Score:  0.564
Data Source:  STRINGDB
ATG16L1
Tbio
Novelty:  0.0031765
Score:  0.549
Data Source:  STRINGDB
WIPI1
Tbio
Novelty:  0.01070744
Score:  0.538
Data Source:  STRINGDB
CALCOCO2
Tbio
Novelty:  0.01456844
Score:  0.53
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
0
1.1
97.4
testosterone measurement
3
3
2
1.1
97.1
sex hormone-binding globulin measurement
4
2
4
93.6
urate measurement
2
2
2
87
serum gamma-glutamyl transferase measurement
3
2
3
65.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
97.4
testosterone measurement
2
1.1
97.1
sex hormone-binding globulin measurement
4
93.6
urate measurement
2
87
serum gamma-glutamyl transferase measurement
3
65.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tectonin beta-propeller repeat containing 1
VGNC:4531
463557
Macaque
tectonin beta-propeller repeat containing 1
706290
Mouse
MGI:1917631
70381
Rat
RGD:1306873
304285
Dog
tectonin beta-propeller repeat containing 1
VGNC:47232
489868
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tectonin beta-propeller repeat containing 1
Macaque
tectonin beta-propeller repeat containing 1
Mouse
Rat
Dog
tectonin beta-propeller repeat containing 1
Publication Statistics
PubMed Score 6.15
PubMed score by year
PubTator Score 2.75
PubTator score by year
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Related Publications
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PMID
Year
Title