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Tbio
NRARP
Notch-regulated ankyrin repeat-containing protein

Protein Summary
Description
Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356628
  • ENSP00000349041
  • ENSG00000198435
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
biological process
0.84
transcription factor perturbation
0.84
PubMedID
0.72
phenotype
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.21   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.21   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (42)
1 – 10 of 42
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.712
Data Source:  STRINGDB
LFNG
Tbio
Family:  Enzyme
Novelty:  0.02660238
Score:  0.663
Data Source:  STRINGDB
DLL4
Tbio
Novelty:  0.00263355
Score:  0.641
Data Source:  STRINGDB
DTX1
Tbio
Family:  Enzyme
Novelty:  0.00972217
Score:  0.638
Data Source:  STRINGDB
HES5
Tbio
Family:  TF
Novelty:  0.00565225
Score:  0.625
Data Source:  STRINGDB
HEY1
Tbio
Family:  TF
Novelty:  0.0042366
Score:  0.617
Data Source:  STRINGDB
DLL1
Tbio
Novelty:  0.00150384
Score:  0.597
Data Source:  STRINGDB
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
Score:  0.591
Data Source:  STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.584
Data Source:  STRINGDB
JAG1
Tbio
Novelty:  0.00107618
Score:  0.573
Data Source:  STRINGDB
Gene Ontology Terms (10)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
MGI
Inferred from Mutant Phenotype (IMP)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
2
3
1.1
90.8
glomerular filtration rate
3
3
4
89.1
creatinine measurement
1
2
2
86.1
mathematical ability
4
2
4
85.2
reticulocyte measurement
3
1
3
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
1.1
90.8
glomerular filtration rate
4
89.1
creatinine measurement
2
86.1
mathematical ability
4
85.2
reticulocyte measurement
3
82.3
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NOTCH regulated ankyrin repeat protein
VGNC:13925
473149
Macaque
NOTCH regulated ankyrin repeat protein
720929
Mouse
MGI:1914372
67122
Dog
NOTCH regulated ankyrin repeat protein
VGNC:43958
100683070
Cow
NOTCH regulated ankyrin repeat protein
VGNC:32252
100299743
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NOTCH regulated ankyrin repeat protein
Macaque
NOTCH regulated ankyrin repeat protein
Mouse
Dog
NOTCH regulated ankyrin repeat protein
Cow
NOTCH regulated ankyrin repeat protein
Publication Statistics
PubMed Score 18.21
PubMed score by year
PubTator Score 5.72
PubTator score by year