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Tbio
ARHGAP30
Rho GTPase-activating protein 30

Protein Summary
Description
GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368013
  • ENSP00000356992
  • ENSG00000186517
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
tissue sample
0.78
virus perturbation
0.76
cell type or tissue
0.72
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.47   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.47   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.936
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.918
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.916
Data Source:  STRINGDB
RHOH
Tbio
Family:  Enzyme
Novelty:  0.00882842
Score:  0.915
Data Source:  STRINGDB
RHOU
Tbio
Family:  Enzyme
Novelty:  0.01456329
Score:  0.914
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.913
Data Source:  STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.907
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.906
Data Source:  STRINGDB
RHOF
Tbio
Family:  Enzyme
Novelty:  0.01795771
Score:  0.904
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
68.2
leukocyte count
1
1
1
66.2
blood protein measurement
2
2
2
58.4
monocyte percentage of leukocytes
1
1
1
45
serum non-albumin protein measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
68.2
leukocyte count
1
66.2
blood protein measurement
2
58.4
monocyte percentage of leukocytes
1
45
serum non-albumin protein measurement
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2684948
226652
Rat
RGD:1561419
498282
Dog
Rho GTPase activating protein 30
VGNC:38057
488647
Horse
Rho GTPase activating protein 30
VGNC:15470
100066336
Cow
Rho GTPase activating protein 30
VGNC:26088
538835
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Rho GTPase activating protein 30
Horse
Rho GTPase activating protein 30
Cow
Rho GTPase activating protein 30
Publication Statistics
PubMed Score 5.47
PubMed score by year
PubTator Score 2.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title