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Tbio
RBBP6
E3 ubiquitin-protein ligase RBBP6

Protein Summary
Description
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pR ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319715
  • ENSP00000317872
  • ENSG00000122257
  • ENST00000348022
  • ENSP00000316291
  • ENST00000381039
  • ENSP00000370427
  • ENST00000452655
  • ENSP00000390537

Symbol
  • P2PR
  • PACT
  • RBQ1
  • PACT
  • MY038
  • P2P-R
  • RBQ-1
  • SNAMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.98
transcription factor perturbation
0.96
interacting protein
0.9
transcription factor binding site profile
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.32   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 318   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.32   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
27.7
body mass index
1
1
1
21.6
body height
1
1
1
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
27.7
body mass index
1
21.6
body height
1
11.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RB binding protein 6, ubiquitin ligase
VGNC:5907
744733
Macaque
RB binding protein 6, ubiquitin ligase
701569
Mouse
MGI:894835
19647
Rat
RGD:1311964
308968
Dog
RB binding protein 6, ubiquitin ligase
VGNC:45392
479802
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RB binding protein 6, ubiquitin ligase
Macaque
RB binding protein 6, ubiquitin ligase
Mouse
Rat
Dog
RB binding protein 6, ubiquitin ligase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7Z6E9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (356)
1 – 10 of 356
ZC3H18
Tdark
Novelty: 0.3515546
p_int: 0.999984835
p_ni: 0.000015165
Score: 0.314
Data Source: BioPlex,STRINGDB
CLK2
Tchem
Family: Kinase
Novelty: 0.13068449
p_int: 0.999754238
p_ni: 0.000245762
Score: 0.797
Data Source: BioPlex,STRINGDB
SAP18
Tbio
Family: Enzyme
Novelty: 0.03918373
p_int: 0.99934833
p_ni: 0.000651668
p_wrong: 2e-9
Data Source: BioPlex
ZNF576
Tdark
Family: TF
Novelty: 13.18548387
p_int: 0.998724476
p_ni: 0.001275524
Score: 0.185
Data Source: BioPlex,STRINGDB
TRPC4AP
Tbio
Novelty: 0.02170224
p_int: 0.99765122
p_ni: 0.00234878
Data Source: BioPlex
TRA2A
Tbio
Novelty: 0.04935993
p_int: 0.996712355
p_ni: 0.003287645
Score: 0.546
Data Source: BioPlex,STRINGDB
CLK3
Tchem
Family: Kinase
Novelty: 0.03466191
p_int: 0.994317895
p_ni: 0.005682105
Score: 0.589
Data Source: BioPlex,STRINGDB
LARP4B
Tbio
Novelty: 0.11363794
p_int: 0.951081577
p_ni: 0.048918256
p_wrong: 1.67e-7
Data Source: BioPlex
RPL7L1
Tdark
Novelty: 0.78428937
p_int: 0.919024411
p_ni: 0.080973306
p_wrong: 0.000002283
Data Source: BioPlex
CDX1
Tbio
Family: TF
Novelty: 0.00815821
p_int: 0.906736693
p_ni: 0.093263307
Data Source: BioPlex
Publication Statistics
PubMed Score  46.32

PubMed score by year
PubTator Score  349.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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