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Tbio
CCDC91
Coiled-coil domain-containing protein 91

Protein Summary
Description
Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381259
  • ENSP00000370658
  • ENSG00000123106
  • ENST00000539107
  • ENSP00000440513
  • ENST00000545336
  • ENSP00000438040

Symbol
  • GGABP
  • p56
  • HSD8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
cell line
0.67
tissue sample
0.65
virus perturbation
0.64
trait
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.38   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.38   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
3
3
3
94.6
forced expiratory volume
3
3
3
93.2
body height
3
3
3
93.1
BMI-adjusted hip circumference
3
11
11
91.8
heel bone mineral density
2
2
3
90.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
3
94.6
forced expiratory volume
3
93.2
body height
3
93.1
BMI-adjusted hip circumference
11
91.8
heel bone mineral density
3
90.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 91
VGNC:51249
465362
Macaque
coiled-coil domain containing 91
710380
Mouse
MGI:1914265
67015
Rat
RGD:1359502
312863
Dog
coiled-coil domain containing 91
VGNC:38872
486622
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 91
Macaque
coiled-coil domain containing 91
Mouse
Rat
Dog
coiled-coil domain containing 91
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7Z6B0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (41)
1 – 10 of 41
GGA1
Tbio
Novelty:  0.00866392
p_int:  0.999973895
p_ni:  0.000026101
p_wrong:  5e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
MVK
Tchem
Family:  Kinase
Novelty:  0.00328607
p_int:  0.999964595
p_ni:  0.000001489
p_wrong:  0.000033916
Score:  0.536
Data Source:  BioPlex,STRINGDB
ANGPTL3
Tclin
Novelty:  0.00595539
p_int:  0.999900211
p_ni:  0.000087844
p_wrong:  0.000011946
Score:  0.332
Data Source:  BioPlex,STRINGDB
STARD7
Tbio
Novelty:  0.04511594
p_int:  0.999887866
p_ni:  0.000112132
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
C10orf88
Tdark
Novelty:  0.49807003
p_int:  0.991722688
p_ni:  0.00827731
p_wrong:  2e-9
Score:  0.217
Data Source:  BioPlex,STRINGDB
CCDC102A
Tdark
Novelty:  1.89784272
p_int:  0.9654595
p_ni:  0.0345405
Score:  0.158
Data Source:  BioPlex,STRINGDB
PES1
Tbio
Novelty:  0.07162845
p_int:  0.877190051
p_ni:  0.000066264
p_wrong:  0.122743685
Data Source:  BioPlex
ESF1
Tbio
Novelty:  0.03295863
Score:  0.675
Data Source:  STRINGDB
GGA2
Tbio
Novelty:  0.01750948
Score:  0.646
Data Source:  STRINGDB
LLPH
Tbio
Novelty:  0.19149323
Score:  0.584
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.38

PubMed score by year
PubTator Score  7.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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