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Tbio
BTLA
B- and T-lymphocyte attenuator

Protein Summary
Description
Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response. This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334529
  • ENSP00000333919
  • ENSG00000186265
  • ENST00000383680
  • ENSP00000373178

Symbol
  • BTLA1
  • CD272
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.69
PubMedID
0.63
tissue sample
0.59
microRNA
0.55
biological term
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.58   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 751   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.58   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 751   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999947317
p_ni:  0.000052682
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.954679445
p_ni:  0.045320555
Data Source:  BioPlex
GCH1
Tbio
Family:  Enzyme
Novelty:  0.0025793
p_int:  0.941125474
p_ni:  0.056293631
p_wrong:  0.002580895
Data Source:  BioPlex
MTHFD2L
Tdark
Family:  Enzyme
Novelty:  0.18530504
p_int:  0.895478608
p_ni:  0.005072549
p_wrong:  0.099448843
Data Source:  BioPlex
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.822685559
p_ni:  0.177314441
Data Source:  BioPlex
TNFRSF14
Tbio
Novelty:  0.00345486
Score:  0.999
Data Source:  Reactome,STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.969
Data Source:  Reactome,STRINGDB
VTCN1
Tbio
Novelty:  0.00565174
Score:  0.961
Data Source:  STRINGDB
PTPN6
Tchem
Family:  Enzyme
Novelty:  0.00535749
Score:  0.945
Data Source:  Reactome,STRINGDB
CD160
Tbio
Novelty:  0.01511748
Score:  0.796
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
1
1
12.7
eosinophil percentage of leukocytes
1
1
1
12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
12.7
eosinophil percentage of leukocytes
1
12
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
B and T lymphocyte associated
VGNC:1749
460584
Macaque
B and T lymphocyte associated
708202
Mouse
MGI:2658978
208154
Rat
RGD:1303280
407756
Dog
B and T lymphocyte associated
VGNC:38561
487975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
B and T lymphocyte associated
Macaque
B and T lymphocyte associated
Mouse
Rat
Dog
B and T lymphocyte associated
Publication Statistics
PubMed Score 170.58
PubMed score by year
PubTator Score 105.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title