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Tbio
BTLA
B- and T-lymphocyte attenuator

Protein Summary
Description
Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response. This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334529
  • ENSP00000333919
  • ENSG00000186265
  • ENST00000383680
  • ENSP00000373178

Symbol
  • BTLA1
  • CD272
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.69
PubMedID
0.63
tissue sample
0.59
microRNA
0.55
biological term
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.72   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 751   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.72   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 751   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
B and T lymphocyte associated
VGNC:1749
460584
Macaque
B and T lymphocyte associated
708202
Mouse
MGI:2658978
208154
Rat
RGD:1303280
407756
Dog
B and T lymphocyte associated
VGNC:38561
487975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
B and T lymphocyte associated
Macaque
B and T lymphocyte associated
Mouse
Rat
Dog
B and T lymphocyte associated
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7Z6A9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Immune System
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (93)
1 – 10 of 93
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.999947317
p_ni: 0.000052682
Data Source: BioPlex
TUBB8
Tclin
Novelty: 0.06403117
p_int: 0.954679445
p_ni: 0.045320555
Data Source: BioPlex
GCH1
Tbio
Family: Enzyme
Novelty: 0.0025793
p_int: 0.941125474
p_ni: 0.056293631
p_wrong: 0.002580895
Data Source: BioPlex
MTHFD2L
Tdark
Family: Enzyme
Novelty: 0.18530504
p_int: 0.895478608
p_ni: 0.005072549
p_wrong: 0.099448843
Data Source: BioPlex
UBR1
Tbio
Family: Enzyme
Novelty: 0.00998888
p_int: 0.822685559
p_ni: 0.177314441
Data Source: BioPlex
TNFRSF14
Tbio
Novelty: 0.00345486
Score: 0.999
Data Source: Reactome,STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.969
Data Source: Reactome,STRINGDB
VTCN1
Tbio
Novelty: 0.00565174
Score: 0.961
Data Source: STRINGDB
PTPN6
Tchem
Family: Enzyme
Novelty: 0.00535749
Score: 0.945
Data Source: Reactome,STRINGDB
CD160
Tbio
Novelty: 0.01511748
Score: 0.796
Data Source: STRINGDB
Publication Statistics
PubMed Score  159.72

PubMed score by year
PubTator Score  105.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer