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Tbio
SPRED1
Sprouty-related, EVH1 domain-containing protein 1

Protein Summary
Description
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity). The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299084
  • ENSP00000299084
  • ENSG00000166068

Symbol
  • LGSS
  • NFLS
  • hSpred1
  • spred-1
  • PPP1R147
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
transcription factor perturbation
0.91
microRNA
0.9
PubMedID
0.82
transcription factor
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.45   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.45   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (104)
1 – 10 of 104
NF1
Tbio
Novelty:  0.00019092
Score:  0.981
Data Source:  Reactome,STRINGDB
RASA1
Tbio
Family:  Enzyme
Novelty:  0.00425286
Score:  0.958
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.954
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.948
Data Source:  STRINGDB
PSMB6
Tbio
Family:  Enzyme
Novelty:  0.04738037
Score:  0.94
Data Source:  STRINGDB
SYNGAP1
Tbio
Family:  Enzyme
Novelty:  0.00570434
Score:  0.94
Data Source:  STRINGDB
RASA2
Tdark
Family:  Enzyme
Novelty:  0.06658896
Score:  0.937
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.933
Data Source:  STRINGDB
FGFRL1
Tbio
Novelty:  0.02178846
Score:  0.913
Data Source:  Reactome,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
Score:  0.909
Data Source:  STRINGDB
Pathways (181)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FGFRL1 modulation of FGFR1 signaling
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FGFRL1 modulation of FGFR1 signaling
FLT3 Signaling
Gene Ontology Terms (22)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
2
2
2
48.3
mathematical ability
2
2
2
32.6
sleep duration
1
1
1
21.5
high density lipoprotein cholesterol measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
2
48.3
mathematical ability
2
32.6
sleep duration
1
21.5
high density lipoprotein cholesterol measurement
1
21.5
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sprouty related EVH1 domain containing 1
VGNC:10259
467654
Macaque
sprouty related EVH1 domain containing 1
100430739
Mouse
MGI:2150016
114715
Rat
RGD:1308735
296072
Dog
sprouty related EVH1 domain containing 1
VGNC:46762
487485
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sprouty related EVH1 domain containing 1
Macaque
sprouty related EVH1 domain containing 1
Mouse
Rat
Dog
sprouty related EVH1 domain containing 1
Publication Statistics
PubMed Score 95.45
PubMed score by year
PubTator Score 61.31
PubTator score by year