Tbio SPRED2 Sprouty-related, EVH1 domain-containing protein 2

Protein Summary

Description

Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q7Z698
• A1L3V4
• B7Z5K7
• D6W5F7
• E9PEP0
• Q2NKX6
• Spred-2

Gene Name

• SPRED2

Ensembl ID

• ENST00000356388
• ENSP00000348753
• ENSG00000198369
• ENST00000443619
• ENSP00000393697

Symbol

• Spred-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.97
kinase perturbation	0.91
transcription factor	0.91
PubMedID	0.85
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Receptor / Sprouty-related, Evh1 Domain-containing Protein 2

DTO Classes

Protein / Receptor / Sprouty-related, Evh1 Domain-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.89   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.89   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0