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Tbio
NET1
Neuroepithelial cell-transforming gene 1 protein

Protein Summary
Description
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355029
  • ENSP00000347134
  • ENSG00000173848
  • ENST00000380359
  • ENSP00000369717

Symbol
  • ARHGEF8
  • NET1A
  • ARHGEF8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
transcription factor perturbation
0.84
hub protein
0.79
kinase perturbation
0.76
gene perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.99   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 382   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.99   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (47)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
NRAGE signals death through JNK
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GPCR downstream signalling
NRAGE signals death through JNK
Protein-Protein Interactions (39)
1 – 10 of 39
IL4R
Tclin
Novelty: 0.00359183
p_int: 0.998712645
p_ni: 0.000007614
p_wrong: 0.001279741
Score: 0.187
Data Source: BioPlex,STRINGDB
WDYHV1
Tbio
Family: Enzyme
Novelty: 0.1844203
p_int: 0.996741458
p_ni: 0.000003128
p_wrong: 0.003255414
Score: 0.171
Data Source: BioPlex,STRINGDB
WDR83
Tbio
Novelty: 0.11602568
p_int: 0.994228666
p_ni: 0.00000239
p_wrong: 0.005768944
Score: 0.2
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.995
Data Source: STRINGDB
RHOB
Tbio
Family: Enzyme
Novelty: 0.0019205
Score: 0.967
Data Source: STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.963
Data Source: STRINGDB
RHOU
Tbio
Family: Enzyme
Novelty: 0.01456329
Score: 0.952
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.95
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.946
Data Source: STRINGDB
RHOBTB1
Tbio
Novelty: 0.02152609
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.99

PubMed score by year
PubTator Score  74.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer