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Tbio
CAMKMT
Calmodulin-lysine N-methyltransferase

Protein Summary
Description
Catalyzes the trimethylation of 'Lys-116' in calmodulin. This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. The protein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378494
  • ENSP00000367755
  • ENSG00000143919
  • ENST00000403853
  • ENSP00000385124

Symbol
  • C2orf34
  • CLNMT
  • Cam
  • KMT
  • CLNMT
  • C2orf34
  • CaM KMT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
histone modification site profile
0.86
trait
0.86
transcription factor perturbation
0.74
small molecule perturbation
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
4
2
1
82.9
body height
2
2
2
78.7
self reported educational attainment
1
1
1
71.9
risk-taking behaviour
2
3
3
66.2
body mass index
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1
82.9
body height
2
78.7
self reported educational attainment
1
71.9
risk-taking behaviour
3
66.2
body mass index
1
54.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
calmodulin-lysine N-methyltransferase
714211
Mouse
MGI:1920832
73582
Rat
RGD:1310453
299521
Dog
calmodulin-lysine N-methyltransferase
VGNC:38685
474575
Cow
calmodulin-lysine N-methyltransferase
VGNC:26727
786620
Species
Name
OMA
EggNOG
Inparanoid
Macaque
calmodulin-lysine N-methyltransferase
Mouse
Rat
Dog
calmodulin-lysine N-methyltransferase
Cow
calmodulin-lysine N-methyltransferase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7Z624-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Metabolism of proteins
Post-translational protein modification
Protein-Protein Interactions (127)
1 – 10 of 127
COL1A2
Tbio
Novelty:  0.00048334
p_int:  0.999966698
p_ni:  3.37e-7
p_wrong:  0.000032965
Score:  0.309
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.998982363
p_ni:  3.41e-7
p_wrong:  0.001017296
Data Source:  BioPlex
COL1A1
Tbio
Novelty:  0.00063584
p_int:  0.994391414
p_ni:  0.005608586
Score:  0.188
Data Source:  BioPlex,STRINGDB
SELENBP1
Tbio
Novelty:  0.00758018
p_int:  0.992285477
p_ni:  0.000001952
p_wrong:  0.007712571
Score:  0.183
Data Source:  BioPlex,STRINGDB
SNX6
Tbio
Novelty:  0.05909848
p_int:  0.983884729
p_ni:  0.016115005
p_wrong:  2.66e-7
Score:  0.159
Data Source:  BioPlex,STRINGDB
HECTD1
Tbio
Family:  Enzyme
Novelty:  0.28016112
p_int:  0.92604183
p_ni:  0.07395817
Score:  0.187
Data Source:  BioPlex,STRINGDB
FEM1B
Tbio
Novelty:  0.06746412
p_int:  0.863585938
p_ni:  0.136413783
p_wrong:  2.79e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
PREPL
Tchem
Family:  Enzyme
Novelty:  0.02310586
Score:  0.914
Data Source:  STRINGDB
PPM1B
Tchem
Family:  Enzyme
Novelty:  0.02370446
Score:  0.906
Data Source:  STRINGDB
SLC3A1
Tbio
Family:  Transporter
Novelty:  0.003328
Score:  0.902
Data Source:  STRINGDB
Publication Statistics
PubMed Score  262.00

PubMed score by year
PubTator Score  13.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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