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Tdark
SNX20
Sorting nexin-20

Protein Summary
Description
May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion. SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.[supplied by OMIM, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300590
  • ENSP00000300590
  • ENSG00000167208
  • ENST00000330943
  • ENSP00000332062
  • ENST00000423026
  • ENSP00000388875
  • ENST00000568993
  • ENSP00000454863

Symbol
  • SLIC1
  • SLIC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
tissue sample
0.71
microRNA
0.67
tissue
0.44
cell line
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.5
97.2
1
1
0
3.6
89.1
heel bone mineral density
1
1
1
85.1
1
1
0
2.1
79.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
97.2
0
3.6
89.1
heel bone mineral density
1
85.1
0
2.1
79.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 20
VGNC:5921
473279
Macaque
sorting nexin 20
695418
Mouse
MGI:1918857
71607
Rat
RGD:1307787
307742
Dog
sorting nexin 20
VGNC:46630
487287
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 20
Macaque
sorting nexin 20
Mouse
Rat
Dog
sorting nexin 20
Protein-Protein Interactions (54)
1 – 10 of 54
JMJD4
Tbio
Novelty: 0.09951585
p_int: 0.999862648
p_ni: 0.000137352
Score: 0.175
Data Source: BioPlex,STRINGDB
DIRAS1
Tbio
Family: Enzyme
Novelty: 0.13332903
p_int: 0.999620331
p_ni: 0.000329729
p_wrong: 0.00004994
Score: 0.211
Data Source: BioPlex,STRINGDB
HCCS
Tbio
Family: Enzyme
Novelty: 0.0022585
p_int: 0.999489178
p_ni: 0.000510392
p_wrong: 4.3e-7
Data Source: BioPlex
VPS13B
Tbio
Novelty: 0.02154769
p_int: 0.996793049
p_ni: 0.003206951
Score: 0.206
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.991956116
p_ni: 0.008043884
Data Source: BioPlex
ENOSF1
Tbio
Family: Enzyme
Novelty: 0.05583478
p_int: 0.985578838
p_ni: 0.014421162
Score: 0.269
Data Source: BioPlex,STRINGDB
AHCYL2
Tbio
Family: Enzyme
Novelty: 0.08695339
p_int: 0.924761386
p_ni: 0.075238614
Data Source: BioPlex
HSPA4
Tbio
Novelty: 0.00009122
p_int: 0.84434012
p_ni: 0.15565988
Score: 0.187
Data Source: BioPlex,STRINGDB
PSMD7
Tbio
Family: Enzyme
Novelty: 0.03090292
p_int: 0.832359667
p_ni: 0.167640333
Data Source: BioPlex
SELPLG
Tbio
Novelty: 0.0016359
Score: 0.856
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.34

PubMed score by year
PubTator Score  1.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer