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Tdark
KCTD20
BTB/POZ domain-containing protein KCTD20

Protein Summary
Description
Promotes the phosphorylation of AKT family members.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373731
  • ENSP00000362836
  • ENSG00000112078
  • ENST00000449081
  • ENSP00000412205
  • ENST00000536244
  • ENSP00000439118

Symbol
  • C6orf69
  • C6orf69
  • dJ108K11.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
disease perturbation
0.79
histone modification site profile
0.79
transcription factor perturbation
0.74
microRNA
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.8   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.8   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (52)
1 – 10 of 52
BUB3
Tbio
Novelty:  0.00714143
p_int:  0.99999965
p_ni:  1e-7
p_wrong:  2.5e-7
Score:  0.297
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999999103
p_ni:  8.96e-7
p_wrong:  1e-9
Score:  0.256
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999995346
p_ni:  0.000003811
p_wrong:  8.42e-7
Score:  0.29
Data Source:  BioPlex,STRINGDB
KCTD19
Tdark
Novelty:  1.14527788
Score:  0.754
Data Source:  STRINGDB
KCTD18
Tdark
Novelty:  0.8176728
Score:  0.754
Data Source:  STRINGDB
KCTD7
Tbio
Novelty:  0.04309568
Score:  0.724
Data Source:  STRINGDB
CLCA2
Tbio
Family:  IC
Novelty:  0.0306541
Score:  0.682
Data Source:  STRINGDB
KCTD5
Tbio
Novelty:  0.07740057
Score:  0.661
Data Source:  STRINGDB
KCNK17
Tchem
Family:  IC
Novelty:  0.04038829
Score:  0.661
Data Source:  STRINGDB
KCTD11
Tchem
Novelty:  0.11239142
Score:  0.644
Data Source:  STRINGDB
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
7
8
99.1
platelet count
5
5
4
5
96.1
2
2
0
1.1
83.2
leukocyte count
1
1
1
38.2
1
1
2
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
8
99.1
platelet count
4
5
96.1
0
1.1
83.2
leukocyte count
1
38.2
2
33.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 20
VGNC:3258
471992
Macaque
potassium channel tetramerization domain containing 20
719159
Mouse
MGI:1914239
66989
Rat
RGD:1309887
294307
Dog
potassium channel tetramerization domain containing 20
VGNC:42306
474889
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 20
Macaque
potassium channel tetramerization domain containing 20
Mouse
Rat
Dog
potassium channel tetramerization domain containing 20
Publication Statistics
PubMed Score 3.80
PubMed score by year
PubTator Score 0.99
PubTator score by year