Tbio APBB1IP Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

Protein Summary

Description

Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.

Uniprot Accession IDs

• Q7Z5R6
• Q8IWS8
• Q8IYL7
• Q8IZZ7

Gene Name

• APBB1IP

Ensembl ID

• ENST00000356785
• ENSP00000349237
• ENSG00000077420
• ENST00000376236
• ENSP00000365411

Symbol

• PREL1
• RARP1
• RIAM
• RIAM
• INAG1
• PREL1
• RARP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
interacting protein	0.77
tissue sample	0.67
phenotype	0.63
PubMedID	0.62

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Amyloid Beta A4 Precursor Protein-binding Family B Member 1-interacting Protein

DTO Classes

Protein / Receptor / Amyloid Beta A4 Precursor Protein-binding Family B Member 1-interacting Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.3   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 201   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.3   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0