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Tbio
POLN
DNA polymerase nu

Protein Classes
Protein Summary
Description
DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template (PubMed:16787914, PubMed:17118716). Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity (PubMed:16787914). Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence (PubMed:25775266). May play a role in TLS during interstrand cross-link (ICL) repair (PubMed:19908865). May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382865
  • ENSP00000372316
  • ENSG00000130997
  • ENST00000511885
  • ENSP00000435506

Symbol
  • POL4P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
cell line
0.59
tissue sample
0.53
cellular component
0.49
molecular function
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.31   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.31   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
45.9
body height
1
1
1
14.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
45.9
body height
1
14.1
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (82)
1 – 10 of 82
FANCD2
Tbio
Novelty: 0.00316101
Score: 0.971
Data Source: Reactome,STRINGDB
FANCA
Tbio
Novelty: 0.00324947
Score: 0.961
Data Source: STRINGDB
FANCI
Tbio
Novelty: 0.01223788
Score: 0.955
Data Source: Reactome,STRINGDB
FANCM
Tbio
Novelty: 0.01122278
Score: 0.948
Data Source: STRINGDB
HELQ
Tbio
Family: Enzyme
Novelty: 0.02982944
Score: 0.947
Data Source: STRINGDB
MUS81
Tbio
Family: Enzyme
Novelty: 0.00532122
Score: 0.947
Data Source: STRINGDB
FANCG
Tbio
Novelty: 0.00908902
Score: 0.944
Data Source: STRINGDB
DCLRE1B
Tbio
Family: Enzyme
Novelty: 0.0598925
Score: 0.943
Data Source: STRINGDB
EME1
Tbio
Family: Enzyme
Novelty: 0.017415
Score: 0.939
Data Source: STRINGDB
SLX4
Tbio
Family: Enzyme
Novelty: 0.01677273
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.31

PubMed score by year
PubTator Score  14.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer