Tbio HSD17B13 17-beta-hydroxysteroid dehydrogenase 13

Protein Summary

Uniprot Accession IDs

• Q7Z5P4
• A8K9R9
• Q2M1L5
• Q86W22
• Q86W23
• 17-beta-HSD 13

Gene Name

• HSD17B13

Ensembl ID

• ENST00000302219
• ENSP00000305438
• ENSG00000170509
• ENST00000328546
• ENSP00000333300

Symbol

• SCDR9
• SDR16C3
• SCDR9
• NIIL497
• SDR16C3
• HMFN0376

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.68
microRNA	0.58
tissue sample	0.53
cell line	0.45
chemical	0.44

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.11   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.11   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	1	1	1		91.6
alcohol abuse	MONDO_0002046	3	1	3		90.5
serum alanine aminotransferase measurement	EFO_0004735	1	1	1		83.3
liver fibrosis measurement	EFO_0010576	1	1	1		79
aspartate aminotransferase measurement	EFO_0004736	1	1	1		78.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	1		91.6
alcohol abuse	MONDO_0002046	3		90.5
serum alanine aminotransferase measurement	EFO_0004735	1		83.3
liver fibrosis measurement	EFO_0010576	1		79
aspartate aminotransferase measurement	EFO_0004736	1		78.6

Reset Zoom  Beta Count   Odds Ratio

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	hydroxysteroid 17-beta dehydrogenase 13	VGNC:48904	471245
Mouse	hydroxysteroid (17-beta) dehydrogenase 13	MGI:2140804	243168
Rat	hydroxysteroid (17-beta) dehydrogenase 13	RGD:1359553	305150
Dog	hydroxysteroid 17-beta dehydrogenase 13	VGNC:41803	478468
Horse	hydroxysteroid 17-beta dehydrogenase 13	VGNC:18885	100052769

Species	Name	OMA	EggNOG	Inparanoid
Chimp	hydroxysteroid 17-beta dehydrogenase 13
Mouse	hydroxysteroid (17-beta) dehydrogenase 13
Rat	hydroxysteroid (17-beta) dehydrogenase 13
Dog	hydroxysteroid 17-beta dehydrogenase 13
Horse	hydroxysteroid 17-beta dehydrogenase 13

Pathways (3)

Reactome (3)

Lipid particle organization (R-HSA-8964572)

Click on a row in the table to change the structure displayed.

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Lipid particle organization	6 targets	R-HSA-8964572
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833

Name	Explore in Pharos	Explore in Source
Lipid particle organization	6 targets	R-HSA-8964572
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833

Gene Ontology Terms (6)

Functions (1)

Components (3)

Processes (2)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
steroid dehydrogenase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (19)

Explore Interacting Targets

1 – 10 of 19

• See Interactions on String-DB

TSPAN10

Tdark

Novelty: 0.19962098

p_int: 0.997588923

p_ni: 0.001604625

p_wrong: 0.000806452

Score: 0.68

Data Source: BioPlex,STRINGDB

FANK1

Tbio

Novelty: 0.12389783

Score: 0.59

Data Source: STRINGDB

ECI2

Tbio

Family: Enzyme

Novelty: 0.02317646

Score: 0.565

Data Source: STRINGDB

NBPF3

Tdark

Novelty: 0.43771383

Score: 0.514

Data Source: STRINGDB

ALDH3A2

Tbio

Family: Enzyme

Novelty: 0.0059198

Score: 0.512

Data Source: STRINGDB

PNPLA3

Tbio

Family: Enzyme

Novelty: 0.00180327

Score: 0.498

Data Source: STRINGDB

SULT4A1

Tbio

Family: Enzyme

Novelty: 0.02455678

Score: 0.495

Data Source: STRINGDB

FRRS1

Tdark

Family: Enzyme

Novelty: 0.04371703

Score: 0.473

Data Source: STRINGDB

SLC16A9

Tbio

Family: Transporter

Novelty: 0.06564904

Score: 0.468

Data Source: STRINGDB

HSD17B4

Tbio

Novelty: 0.00547499

Score: 0.465

Data Source: STRINGDB

Publication Statistics

PubMed Score  34.11

PubMed score by year

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PubTator Score  123.35

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Complete proteome
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

alcohol abuse
aspartate aminotransferase measurement
liver fibrosis measurement
platelet count
serum alanine aminotransferase measurement
sex hormone-binding globulin measurement
testosterone measurement
triglyceride measurement