Protein Summary
Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
- ENST00000404826
- ENSP00000385899
- ENSG00000146555
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.97 | ||
protein domain | 0.85 | ||
transcription factor binding site profile | 0.78 | ||
cell type or tissue | 0.73 | ||
histone modification site profile | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.23 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 30 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.23 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 30 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (35)
LGALS3
Novelty: 0.00032754
p_int: 0.999999932
p_ni: 1.3e-8
p_wrong: 5.5e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
LGALS8
Novelty: 0.00623836
p_int: 0.999996565
p_ni: 0.00000155
p_wrong: 0.000001885
Score: 0.201
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | SDK interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
SDK interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (4)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 7 | 8 | 93.6 | |||||
smoking status measurement | 3 | 2 | 3 | 1 | 89.4 | ||||
smoking initiation | 3 | 3 | 3 | 85.2 | |||||
self reported educational attainment | 1 | 1 | 1 | 75.4 | |||||
smoking behavior | 1 | 2 | 2 | 71.8 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 8 | 93.6 | |||||
smoking status measurement | 3 | 1 | 89.4 | ||||
smoking initiation | 3 | 85.2 | |||||
self reported educational attainment | 1 | 75.4 | |||||
smoking behavior | 2 | 71.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | sidekick cell adhesion molecule 1 | VGNC:4502 | 463240 | |||||
Macaque | sidekick cell adhesion molecule 1 | 715160 | ||||||
Mouse | MGI:2444413 | 330222 | ||||||
Dog | sidekick cell adhesion molecule 1 | VGNC:45953 | 489886 | |||||
Horse | sidekick cell adhesion molecule 1 | VGNC:22775 | 100060475 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | sidekick cell adhesion molecule 1 | |||||
Macaque | sidekick cell adhesion molecule 1 | |||||
Mouse | ||||||
Dog | sidekick cell adhesion molecule 1 | |||||
Horse | sidekick cell adhesion molecule 1 | |||||
Publication Statistics
PubMed Score 23.23
PubMed score by year
PubTator Score 7.62
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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