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Tbio
WAPL
Wings apart-like protein homolog

Protein Summary
Description
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298767
  • ENSP00000298767
  • ENSG00000062650
  • ENST00000618527
  • ENSP00000481451

Symbol
  • FOE
  • KIAA0261
  • WAPAL
  • FOE
  • WAPAL
  • KIAA0261
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.65   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.65   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
62.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
62.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WAPL cohesin release factor
VGNC:7274
450568
Macaque
WAPL cohesin release factor
700171
Mouse
MGI:2675859
218914
Dog
WAPL cohesin release factor
VGNC:48330
612854
Horse
WAPL cohesin release factor
VGNC:24963
100052524
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WAPL cohesin release factor
Macaque
WAPL cohesin release factor
Mouse
Dog
WAPL cohesin release factor
Horse
WAPL cohesin release factor
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7Z5K2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cohesin Loading onto Chromatin
Reactome
Establishment of Sister Chromatid Cohesion
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cohesin Loading onto Chromatin
Establishment of Sister Chromatid Cohesion
M Phase
Gene Ontology Terms (21)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (162)
1 – 10 of 162
RAD21
Tbio
Novelty: 0.00270936
p_int: 0.999999187
p_ni: 8.13e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.999998019
p_ni: 0.000001981
Data Source: BioPlex
COMTD1
Tdark
Family: Enzyme
Novelty: 0.245971
p_int: 0.999974898
p_ni: 0.000025102
Data Source: BioPlex
ST6GAL1
Tchem
Family: Enzyme
Novelty: 0.00274127
p_int: 0.995357106
p_ni: 0.004642881
p_wrong: 1.3e-8
Score: 0.181
Data Source: BioPlex,STRINGDB
ATG4C
Tbio
Family: Enzyme
Novelty: 0.04175533
p_int: 0.993989627
p_ni: 0.006010365
p_wrong: 8e-9
Data Source: BioPlex
GREM2
Tbio
Novelty: 0.01839564
p_int: 0.991828083
p_ni: 0.008171905
p_wrong: 1.2e-8
Data Source: BioPlex
SCCPDH
Tbio
Family: Enzyme
Novelty: 0.06603568
p_int: 0.99153089
p_ni: 0.00846911
Data Source: BioPlex
DNAJC10
Tbio
Novelty: 0.02258366
p_int: 0.988381736
p_ni: 0.011618264
Score: 0.201
Data Source: BioPlex,STRINGDB
TULP3
Tbio
Family: TF
Novelty: 0.06911636
p_int: 0.987716482
p_ni: 0.012283518
Data Source: BioPlex
CDKN2AIP
Tbio
Novelty: 0.15331029
p_int: 0.982480339
p_ni: 0.017519635
p_wrong: 2.6e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  58.65

PubMed score by year
PubTator Score  158.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer