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Tbio
RAI1
Retinoic acid-induced protein 1

Protein Summary
Description
Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. This gene is located within the Smith-Magenis syndrome region on chromosome 17. It is highly similar to its mouse counterpart and is expressed at high levels mainly in neuronal tissues. The protein encoded by this gene includes a polymorphic polyglutamine tract in the N-terminal domain. Expression of the mouse counterpart in neurons is induced by retinoic acid. This gene is associated with both the severity of the phenotype and the response to medication in schizophrenic patients. [provided by RefSeq ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353383
  • ENSP00000323074
  • ENSG00000108557

Symbol
  • KIAA1820
  • SMS
  • SMCR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
virus perturbation
0.85
transcription factor
0.79
tissue sample
0.7
PubMedID
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.89   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.89   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
p_int:  0.999999741
p_ni:  3.5e-8
p_wrong:  2.25e-7
Score:  0.356
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.999998964
p_ni:  0.000001035
p_wrong:  2e-9
Score:  0.312
Data Source:  BioPlex,STRINGDB
CLOCK
Tbio
Family:  TF; Epigenetic
Novelty:  0.00159625
Score:  0.923
Data Source:  STRINGDB
EXOSC10
Tbio
Novelty:  0.00335571
Score:  0.811
Data Source:  STRINGDB
DXO
Tbio
Family:  Enzyme
Novelty:  0.08260087
Score:  0.747
Data Source:  STRINGDB
EXOSC7
Tbio
Family:  Enzyme
Novelty:  0.07422851
Score:  0.742
Data Source:  STRINGDB
EXOSC4
Tbio
Family:  Enzyme
Novelty:  0.00798796
Score:  0.707
Data Source:  STRINGDB
TCF20
Tbio
Family:  Epigenetic
Novelty:  0.00089239
Score:  0.682
Data Source:  STRINGDB
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
Score:  0.641
Data Source:  STRINGDB
ULK2
Tchem
Family:  Kinase
Novelty:  0.02285321
Score:  0.623
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
15
15
95.7
waist-hip ratio
3
16
16
89.8
hip circumference
3
11
11
87.4
lymphocyte count
2
2
2
86.8
sex hormone-binding globulin measurement
2
1
2
81.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
15
95.7
waist-hip ratio
16
89.8
hip circumference
11
87.4
lymphocyte count
2
86.8
sex hormone-binding globulin measurement
2
81.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinoic acid induced 1
VGNC:9551
743919
Macaque
retinoic acid induced 1
699215
Mouse
MGI:103291
19377
Rat
RGD:1308500
303188
Dog
retinoic acid induced 1
VGNC:45328
489541
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinoic acid induced 1
Macaque
retinoic acid induced 1
Mouse
Rat
Dog
retinoic acid induced 1
Publication Statistics
PubMed Score 104.89
PubMed score by year
PubTator Score 86.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title