Tbio RIC3 Protein RIC-3

Protein Summary

Description

Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q7Z5B4
• B0B1U0
• B2RD25
• D3DQU5
• Q6UX78
• Q7Z5B3
• Q86T94
• Q8TBJ9
• Q9HAH8

Gene Name

• RIC3

Ensembl ID

• ENST00000309737
• ENSP00000308820
• ENSG00000166405
• ENST00000335425
• ENSP00000333988
• ENST00000343202
• ENSP00000344904
• ENST00000419822
• ENSP00000404415
• ENST00000425599
• ENSP00000395320

Symbol

• AYST720
• PRO1385

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.72
cellular component	0.64
histone modification site profile	0.64
tissue	0.53
tissue sample	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.9   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.9   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0