You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FAM19A1
Protein FAM19A1

Protein Summary
Description
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000478136
  • ENSP00000418575
  • ENSG00000183662
  • ENST00000496687
  • ENSP00000417496

Symbol
  • TAFA1
  • TAFA-1
  • FAM19A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.7
microRNA
0.64
disease
0.61
cell type or tissue
0.56
trait
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.52   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.52   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
1
2
78
physical activity measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
78
physical activity measurement
1
31.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 19 member A1, C-C motif chemokine like
VGNC:11393
736053
Macaque
family with sequence similarity 19 member A1, C-C motif chemokine like
697220
Mouse
MGI:2443695
320265
Dog
family with sequence similarity 19 member A1, C-C motif chemokine like [Source:HGNC Symbol;Acc:HGNC:21587]
Horse
family with sequence similarity 19 member A1, C-C motif chemokine like
VGNC:17841
100053538
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 19 member A1, C-C motif chemokine like
Macaque
family with sequence similarity 19 member A1, C-C motif chemokine like
Mouse
Dog
family with sequence similarity 19 member A1, C-C motif chemokine like [Source:HGNC Symbol;Acc:HGNC:21587]
Horse
family with sequence similarity 19 member A1, C-C motif chemokine like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z5A9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (40)
1 – 10 of 40
NRXN3
Tbio
Novelty:  0.00999084
p_int:  0.999870207
p_ni:  0.000120389
p_wrong:  0.000009404
Score:  0.343
Data Source:  BioPlex,STRINGDB
ZER1
Tbio
Novelty:  0.02989698
p_int:  0.810101057
p_ni:  0.189898943
Score:  0.206
Data Source:  BioPlex,STRINGDB
M6PR
Tbio
Novelty:  0.00210407
p_int:  0.77682056
p_ni:  0.22317944
Score:  0.485
Data Source:  BioPlex,STRINGDB
ZNF385D
Tdark
Novelty:  0.29119721
Score:  0.763
Data Source:  STRINGDB
DENND2A
Tbio
Novelty:  0.75514881
Score:  0.712
Data Source:  STRINGDB
CLEC2L
Tdark
Novelty:  1.56480599
Score:  0.674
Data Source:  STRINGDB
TMEM179
Tdark
Novelty:  2.21288966
Score:  0.651
Data Source:  STRINGDB
TMEM130
Tdark
Novelty:  1.39618601
Score:  0.64
Data Source:  STRINGDB
TMEM88B
Tdark
Novelty:  1.83653775
Score:  0.63
Data Source:  STRINGDB
AMER3
Tdark
Novelty:  0.42348252
Score:  0.622
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.52

PubMed score by year
PubTator Score  0.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer