You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
PRSS42
Serine protease 42

Protein Classes
Protein Summary
Description
This gene encodes a member of a cluster of testis-specific serine proteases. The orthologous mouse gene is expressed during meiosis in pachytene spermatocytes and is required for germ cell survival. This human locus is represented as a pseudogene because it contains an early stop codon that disrupts the trypsin domain, compared to the mouse ortholog. [provided by RefSeq, Jan 2019]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000429665
  • ENSP00000401701
  • ENSG00000178055

Symbol
  • TESSP2
  • PRSS42
  • TESSP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
tissue sample
0.64
tissue
0.62
protein domain
0.58
gene perturbation
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.17   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.17   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (4)
1 – 4 of 4
PRSS45
Tdark
Family: Enzyme
Novelty: 0.62890615
Score: 0.486
Data Source: STRINGDB
LMCD1
Tbio
Novelty: 0.06810419
Score: 0.446
Data Source: STRINGDB
LRRC58
Tdark
Novelty: 2.4415805
Score: 0.435
Data Source: STRINGDB
AIP
Tbio
Novelty: 0.00869592
Score: 0.421
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.17

PubMed score by year
PubTator Score  0.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer