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Tbio
EMSY
BRCA2-interacting transcriptional repressor EMSY

Protein Summary
Description
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334736
  • ENSP00000334130
  • ENSG00000158636
  • ENST00000524767
  • ENSP00000433205
  • ENST00000525038
  • ENSP00000436968
  • ENST00000525919
  • ENSP00000432010
  • ENST00000529032
  • ENSP00000432327
  • ENST00000533248
  • ENSP00000433634
  • ENST00000533988
  • ENSP00000434665

Symbol
  • C11orf30
  • GL002
  • C11orf30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.94   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.94   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
8
0
1.1
99.6
4
4
0
1.1
99
Eczema
3
2
0
1.1
96.9
childhood onset asthma
3
5
0
1.3
96.9
4
4
0
1.2
96.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
99.6
0
1.1
99
Eczema
0
1.1
96.9
childhood onset asthma
0
1.3
96.9
0
1.2
96.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EMSY, BRCA2 interacting transcriptional repressor
VGNC:7648
466716
Macaque
EMSY, BRCA2 interacting transcriptional repressor
697319
Mouse
MGI:1924203
233545
Rat
RGD:1310712
361607
Dog
EMSY, BRCA2 interacting transcriptional repressor
VGNC:40355
476800
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EMSY, BRCA2 interacting transcriptional repressor
Macaque
EMSY, BRCA2 interacting transcriptional repressor
Mouse
Rat
Dog
EMSY, BRCA2 interacting transcriptional repressor
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7Z589-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (60)
1 – 10 of 60
MORF4L1
Tbio
Family: Epigenetic
Novelty: 0.01696001
p_int: 0.999999862
p_ni: 1.34e-7
p_wrong: 4e-9
Score: 0.836
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999995709
p_ni: 0.000004291
Score: 0.332
Data Source: BioPlex,STRINGDB
FBLIM1
Tbio
Novelty: 0.0332985
p_int: 0.997588917
p_ni: 0.000470306
p_wrong: 0.001940777
Data Source: BioPlex
TMEM171
Tdark
Novelty: 2.00247773
p_int: 0.99222956
p_ni: 0.007764845
p_wrong: 0.000005595
Score: 0.181
Data Source: BioPlex,STRINGDB
NCAPH2
Tbio
Novelty: 0.12134933
p_int: 0.763879361
p_ni: 0.036484393
p_wrong: 0.199636246
Data Source: BioPlex
BRCA2
Tbio
Novelty: 0.0002217
Score: 0.965
Data Source: STRINGDB
ZMYND11
Tbio
Family: Epigenetic
Novelty: 0.02485283
Score: 0.884
Data Source: STRINGDB
AIDA
Tbio
Novelty: 0.7243992
Score: 0.8
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00011146
Score: 0.778
Data Source: STRINGDB
CBX1
Tbio
Family: Epigenetic
Novelty: 0.00343221
Score: 0.76
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.94

PubMed score by year
PubTator Score  33.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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