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Tbio
BRAP
BRCA1-associated protein

Protein Summary
Description
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419234
  • ENSP00000403524
  • ENSG00000089234

Symbol
  • RNF52
  • IMP
  • BRAP2
  • RNF52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
histone modification site profile
0.94
molecular function
0.86
virus perturbation
0.83
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.53   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.53   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
KLHDC3
Tdark
Novelty:  0.63840156
p_int:  0.999999485
p_ni:  4.33e-7
p_wrong:  8.2e-8
Score:  0.295
Data Source:  BioPlex,STRINGDB
SERPINB13
Tbio
Novelty:  0.01753451
p_int:  0.999972571
p_ni:  0.000027414
p_wrong:  1.4e-8
Score:  0.202
Data Source:  BioPlex,STRINGDB
PRODH
Tbio
Family:  Enzyme
Novelty:  0.00315806
p_int:  0.999944792
p_ni:  0.000055202
p_wrong:  6e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
EFHC1
Tbio
Novelty:  0.01722469
p_int:  0.999550949
p_ni:  0.000095115
p_wrong:  0.000353936
Score:  0.393
Data Source:  BioPlex,STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.978
Data Source:  STRINGDB
KSR1
Tbio
Family:  Kinase
Novelty:  0.00691155
Score:  0.969
Data Source:  Reactome,STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.967
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.963
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.961
Data Source:  STRINGDB
RAF1
Tclin
Family:  Kinase
Novelty:  0.00117121
Score:  0.949
Data Source:  STRINGDB
Pathways (58)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (54)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
3
3
97.9
mean corpuscular volume
2
3
3
97
mean corpuscular hemoglobin concentration
2
2
2
95.1
platelet count
4
4
3
3.7
94.2
alkaline phosphatase measurement
2
2
2
92.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
3
97.9
mean corpuscular volume
3
97
mean corpuscular hemoglobin concentration
2
95.1
platelet count
3
3.7
94.2
alkaline phosphatase measurement
2
92.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BRCA1 associated protein
VGNC:4950
452249
Macaque
BRCA1 associated protein
713386
Mouse
MGI:1919649
72399
Dog
BRCA1 associated protein
VGNC:38515
486271
Horse
BRCA1 associated protein
VGNC:15876
100057742
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BRCA1 associated protein
Macaque
BRCA1 associated protein
Mouse
Dog
BRCA1 associated protein
Horse
BRCA1 associated protein
Publication Statistics
PubMed Score 41.53
PubMed score by year
PubTator Score 40.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title