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Tdark
KRTAP19-3
Keratin-associated protein 19-3

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334063
  • ENSP00000386376
  • ENSG00000244025

Symbol
  • KAP19.3
  • GTRHP
  • KAP19.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.44
cell line
0.35
tissue sample
0.31
microRNA
0.3
cellular component
0.23


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (89)
1 – 10 of 89
KRTAP7-1
Tdark
Novelty:  0.31372157
Score:  0.671
Data Source:  STRINGDB
KRTAP8-1
Tbio
Novelty:  0.18211237
Score:  0.648
Data Source:  STRINGDB
KRTAP21-2
Tdark
Novelty:  0.86372091
Score:  0.641
Data Source:  STRINGDB
KRTAP19-4
Tdark
Novelty:  217
Score:  0.626
Data Source:  STRINGDB
KRTAP20-1
Tdark
Novelty:  0.5308345
Score:  0.609
Data Source:  STRINGDB
KRTAP10-7
Tdark
Novelty:  2.11523903
Score:  0.608
Data Source:  STRINGDB
KRTAP13-2
Tdark
Novelty:  9.95747062
Score:  0.607
Data Source:  STRINGDB
KRTAP19-7
Tdark
Novelty:  63.61563518
Score:  0.604
Data Source:  STRINGDB
KRTAP10-5
Tdark
Novelty:  3.58424816
Score:  0.603
Data Source:  STRINGDB
KRTAP20-2
Tdark
Novelty:  1.77962785
Score:  0.602
Data Source:  STRINGDB
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Publication Statistics
PubMed Score 0.50
PubMed score by year