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Tbio
HDGFL2
Hepatoma-derived growth factor-related protein 2

Protein Summary
Description
Involved in cellular growth control, through the regulation of cyclin D1 expression. This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000616600
  • ENSP00000483345
  • ENSG00000167674
  • ENST00000621835
  • ENSP00000483702

Symbol
  • HDGF2
  • HDGFRP2
  • HRP2
  • HRP2
  • HDGF2
  • HRP-2
  • HDGF-2
  • HDGFRP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.36   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.36   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
2
3
89.4
mean corpuscular hemoglobin concentration
3
1
3
88.6
sex hormone-binding globulin measurement
2
2
2
86.1
mean corpuscular volume
2
2
2
82.4
low density lipoprotein cholesterol measurement
2
2
2
78.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
89.4
mean corpuscular hemoglobin concentration
3
88.6
sex hormone-binding globulin measurement
2
86.1
mean corpuscular volume
2
82.4
low density lipoprotein cholesterol measurement
2
78.5
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7Z4V5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (92)
1 – 10 of 92
IWS1
Tbio
Novelty: 0.08732963
p_int: 1
Score: 0.525
Data Source: BioPlex,STRINGDB
CHAMP1
Tbio
Novelty: 0.09520274
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.195
Data Source: BioPlex,STRINGDB
HDGFL3
Tbio
Family: Epigenetic
Novelty: 0.14292821
p_int: 0.999999947
p_ni: 2e-9
p_wrong: 5.1e-8
Data Source: BioPlex
POGZ
Tbio
Novelty: 0.03603188
p_int: 0.999999936
p_ni: 9e-9
p_wrong: 5.7e-8
Score: 0.844
Data Source: BioPlex,STRINGDB
PIP4K2C
Tchem
Family: Kinase
Novelty: 0.11466436
p_int: 0.999998557
p_ni: 0.000001443
Data Source: BioPlex
DPF3
Tbio
Family: Epigenetic
Novelty: 0.069151
p_int: 0.999997816
p_ni: 0.000002183
p_wrong: 1e-9
Data Source: BioPlex
PIP4K2B
Tchem
Family: Kinase
Novelty: 0.06261627
p_int: 0.999996966
p_ni: 0.000003034
Data Source: BioPlex
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
p_int: 0.999996572
p_ni: 0.000003428
Score: 0.254
Data Source: BioPlex,STRINGDB
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.999994488
p_ni: 0.000005504
p_wrong: 9e-9
Data Source: BioPlex
NFKBIL1
Tbio
Novelty: 0.03932489
p_int: 0.999993816
p_ni: 0.000006166
p_wrong: 1.9e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  7.36

PubMed score by year
PubTator Score  143.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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