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Tbio
KIF21A
Kinesin-like protein KIF21A

Protein Summary
Description
Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity). This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361418
  • ENSP00000354878
  • ENSG00000139116
  • ENST00000361961
  • ENSP00000354851
  • ENST00000541463
  • ENSP00000438075
  • ENST00000544797
  • ENSP00000445606

Symbol
  • KIAA1708
  • KIF2
  • FEOM1
  • CFEOM1
  • FEOM3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.98
kinase perturbation
0.91
interacting protein
0.9
transcription factor binding site profile
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.37   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.37   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.999999995
p_ni:  5e-9
Score:  0.259
Data Source:  BioPlex,STRINGDB
KANK1
Tbio
Novelty:  0.02077359
Score:  0.986
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
KIF11
Tchem
Novelty:  0.00170673
Score:  0.951
Data Source:  STRINGDB
KIFAP3
Tbio
Novelty:  0.01902437
Score:  0.945
Data Source:  STRINGDB
KANK2
Tbio
Novelty:  0.06232448
Score:  0.945
Data Source:  STRINGDB
KIF5A
Tbio
Novelty:  0.01277095
Score:  0.944
Data Source:  STRINGDB
KIF5B
Tbio
Novelty:  0.00515256
Score:  0.94
Data Source:  STRINGDB
KIF1A
Tbio
Novelty:  0.00505209
Score:  0.939
Data Source:  STRINGDB
KIF20B
Tbio
Novelty:  0.0465712
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Intra-Golgi and retrograde Golgi-to-ER traffic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
2.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
2.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
kinesin family member 21A
699150
Mouse
MGI:109188
16564
Rat
RGD:1305126
300158
Dog
kinesin family member 21A
VGNC:42396
100683402
Horse
kinesin family member 21A
VGNC:19407
100070369
Species
Name
OMA
EggNOG
Inparanoid
Macaque
kinesin family member 21A
Mouse
Rat
Dog
kinesin family member 21A
Horse
kinesin family member 21A
Publication Statistics
PubMed Score 68.37
PubMed score by year
PubTator Score 53.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title