KIF21A
Kinesin-like protein KIF21A
Protein Summary
Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity). This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
- ENST00000361418
- ENSP00000354878
- ENSG00000139116
- ENST00000361961
- ENSP00000354851
- ENST00000541463
- ENSP00000438075
- ENST00000544797
- ENSP00000445606
- KIAA1708
- KIF2
- FEOM1
- CFEOM1
- FEOM3A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
molecular function | 0.98 | ||
kinase perturbation | 0.91 | ||
interacting protein | 0.9 | ||
transcription factor binding site profile | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 75.73 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 52 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 75.73 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 52 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0