Tbio P4HA3 Prolyl 4-hydroxylase subunit alpha-3

Protein Summary

Description

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• Q7Z4N8
• A0AV13
• B4DUD3
• Q5EBL3
• Q5JPA9
• 4-PH alpha-3

Gene Name

• P4HA3

Ensembl ID

• ENST00000331597
• ENSP00000332170
• ENSG00000149380
• ENST00000427714
• ENSP00000401749
• ENST00000524388
• ENSP00000433860

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
cell type or tissue	0.79
histone modification site profile	0.71
gene perturbation	0.68
cell line	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.51   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.51   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (144)

Explore Interacting Targets

1 – 10 of 144

• See Interactions on String-DB

ZBTB7B

Tbio

Family:  TF

Novelty:  0.01942129

p_int:  1

Score:  0.255

Data Source:  BioPlex,STRINGDB

KIF21A

Tbio

Novelty:  0.01535562

p_int:  0.999999995

p_ni:  5e-9

Score:  0.259

Data Source:  BioPlex,STRINGDB

ZMYND8

Tbio

Family:  Epigenetic

Novelty:  0.05352096

p_int:  0.999999958

p_ni:  4.2e-8

Score:  0.182

Data Source:  BioPlex,STRINGDB

KMT2B

Tbio

Family:  Epigenetic

Novelty:  0.00593529

p_int:  0.999999884

p_ni:  1.16e-7

Score:  0.196

Data Source:  BioPlex,STRINGDB

ZNF687

Tbio

Family:  TF

Novelty:  0.14707532

p_int:  0.999999514

p_ni:  4.86e-7

Data Source:  BioPlex

AGAP1

Tbio

Family:  Enzyme

Novelty:  0.06776705

p_int:  0.999998336

p_ni:  0.000001658

p_wrong:  7e-9

Data Source:  BioPlex

SATB1

Tbio

Family:  TF

Novelty:  0.00434577

p_int:  0.999996194

p_ni:  0.000003802

p_wrong:  4e-9

Data Source:  BioPlex

PWWP2A

Tdark

Novelty:  0.1712947

p_int:  0.999992404

p_ni:  0.000007562

p_wrong:  3.4e-8

Data Source:  BioPlex

SLBP

Tbio

Novelty:  0.00685735

p_int:  0.999992292

p_ni:  0.000004018

p_wrong:  0.000003691

Score:  0.177

Data Source:  BioPlex,STRINGDB

FAM120C

Tbio

Novelty:  0.03333181

p_int:  0.999989761

p_ni:  0.000010236

p_wrong:  3e-9

Score:  0.237

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (3)

KEGG (2)

Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Collagen biosynthesis and modifying enzymes	67 targets	R-HSA-1650814
Reactome	Collagen formation	90 targets	R-HSA-1474290
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244

Name	Explore in Pharos	Explore in Source
Collagen biosynthesis and modifying enzymes	67 targets	R-HSA-1650814
Collagen formation	90 targets	R-HSA-1474290
Extracellular matrix organization	297 targets	R-HSA-1474244

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (4)

Components (2)

Processes (1)

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1 – 4 of 4

GO Term	Evidence	Assigned by
iron ion binding	Inferred from Electronic Annotation (IEA)	InterPro
L-ascorbic acid binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Inferred from Electronic Annotation (IEA)	InterPro
procollagen-proline 4-dioxygenase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hematocrit	EFO_0004348	1	1	1		12.2
hemoglobin measurement	EFO_0004509	1	1	1		7.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hematocrit	EFO_0004348	1		12.2
hemoglobin measurement	EFO_0004509	1		7.2

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Coiled coil
Complete proteome
Dioxygenase
Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Oxidoreductase
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
hematocrit
hemoglobin measurement

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	prolyl 4-hydroxylase subunit alpha 3	VGNC:7673	748564
Macaque	prolyl 4-hydroxylase subunit alpha 3		718872
Mouse	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III	MGI:2444049	320452
Rat	prolyl 4-hydroxylase subunit alpha 3	RGD:735150	361612
Dog	prolyl 4-hydroxylase subunit alpha 3	VGNC:44224	609381

Species	Name	OMA	EggNOG	Inparanoid
Chimp	prolyl 4-hydroxylase subunit alpha 3
Macaque	prolyl 4-hydroxylase subunit alpha 3
Mouse	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
Rat	prolyl 4-hydroxylase subunit alpha 3
Dog	prolyl 4-hydroxylase subunit alpha 3

Publication Statistics

PubMed Score 28.51

PubMed score by year

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PubTator Score 1.96

PubTator score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (4)

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10

0 of 0

PMID	Year	Title