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Tbio
P4HA3
Prolyl 4-hydroxylase subunit alpha-3

Protein Summary
Description
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331597
  • ENSP00000332170
  • ENSG00000149380
  • ENST00000427714
  • ENSP00000401749
  • ENST00000524388
  • ENSP00000433860
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
cell type or tissue
0.79
histone modification site profile
0.71
gene perturbation
0.68
cell line
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.75   (req: < 5)
View Publications
Gene RIFs: 4   (req: <= 3)
View Gene RIFs
Antibodies: 130   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.75   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prolyl 4-hydroxylase subunit alpha 3
VGNC:7673
748564
Macaque
prolyl 4-hydroxylase subunit alpha 3
718872
Mouse
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
MGI:2444049
320452
Rat
prolyl 4-hydroxylase subunit alpha 3
RGD:735150
361612
Dog
prolyl 4-hydroxylase subunit alpha 3
VGNC:44224
609381
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prolyl 4-hydroxylase subunit alpha 3
Macaque
prolyl 4-hydroxylase subunit alpha 3
Mouse
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
Rat
prolyl 4-hydroxylase subunit alpha 3
Dog
prolyl 4-hydroxylase subunit alpha 3
Pathways (5)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
67 targets
R-HSA-1650814
Reactome
Collagen formation
90 targets
R-HSA-1474290
Reactome
Extracellular matrix organization
297 targets
R-HSA-1474244
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
67 targets
R-HSA-1650814
Collagen formation
90 targets
R-HSA-1474290
Extracellular matrix organization
297 targets
R-HSA-1474244
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
iron ion binding
Inferred from Electronic Annotation (IEA)
InterPro
L-ascorbic acid binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Inferred from Electronic Annotation (IEA)
InterPro
procollagen-proline 4-dioxygenase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (144)
1 – 10 of 144
ZBTB7B
Tbio
Family: TF
Novelty: 0.01942129
p_int: 1
Score: 0.255
Data Source: BioPlex,STRINGDB
KIF21A
Tbio
Novelty: 0.01535562
p_int: 0.999999995
p_ni: 5e-9
Score: 0.259
Data Source: BioPlex,STRINGDB
ZMYND8
Tbio
Family: Epigenetic
Novelty: 0.05352096
p_int: 0.999999958
p_ni: 4.2e-8
Score: 0.182
Data Source: BioPlex,STRINGDB
KMT2B
Tbio
Family: Epigenetic
Novelty: 0.00593529
p_int: 0.999999884
p_ni: 1.16e-7
Score: 0.196
Data Source: BioPlex,STRINGDB
ZNF687
Tbio
Family: TF
Novelty: 0.14707532
p_int: 0.999999514
p_ni: 4.86e-7
Data Source: BioPlex
AGAP1
Tbio
Family: Enzyme
Novelty: 0.06776705
p_int: 0.999998336
p_ni: 0.000001658
p_wrong: 7e-9
Data Source: BioPlex
SATB1
Tbio
Family: TF
Novelty: 0.00434577
p_int: 0.999996194
p_ni: 0.000003802
p_wrong: 4e-9
Data Source: BioPlex
PWWP2A
Tdark
Novelty: 0.1712947
p_int: 0.999992404
p_ni: 0.000007562
p_wrong: 3.4e-8
Data Source: BioPlex
SLBP
Tbio
Novelty: 0.00685735
p_int: 0.999992292
p_ni: 0.000004018
p_wrong: 0.000003691
Score: 0.177
Data Source: BioPlex,STRINGDB
FAM120C
Tbio
Novelty: 0.03333181
p_int: 0.999989761
p_ni: 0.000010236
p_wrong: 3e-9
Score: 0.237
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  25.75

PubMed score by year
PubTator Score  1.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer