Tbio TRIM46 Tripartite motif-containing protein 46

Protein Summary

Description

Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.

Uniprot Accession IDs

• Q7Z4K8
• A0AVI6
• B1AVQ4
• Q5VT60
• Q5VT62
• Q6NT17
• Q6NT41
• Q6ZRL7
• Q9H5P2

Gene Name

• TRIM46

Ensembl ID

• ENST00000334634
• ENSP00000334657
• ENSG00000163462
• ENST00000368382
• ENSP00000357366
• ENST00000368385
• ENSP00000357369
• ENST00000543729
• ENSP00000442719

Symbol

• TRIFIC
• GENEY
• TRIFIC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
transcription factor	0.78
histone modification site profile	0.74
transcription factor binding site profile	0.63
tissue sample	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.12   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.12   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0