Tbio LIMS2 LIM and senescent cell antigen-like-containing domain protein 2

Protein Summary

Description

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration. This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q7Z4I7
• A6NLH0
• B4DMV1
• F5H6E6
• Q7Z4I2
• Q7Z4I6
• Q7Z4I8
• Q8NFE7
• Q9HA13

Gene Name

• LIMS2

Ensembl ID

• ENST00000324938
• ENSP00000326888
• ENSG00000072163
• ENST00000355119
• ENSP00000347240
• ENST00000409254
• ENSP00000386907
• ENST00000409286
• ENSP00000386252
• ENST00000409455
• ENSP00000386383
• ENST00000409754
• ENSP00000386345
• ENST00000409808
• ENSP00000386637
• ENST00000410011
• ENSP00000387002
• ENST00000410038
• ENSP00000386570
• ENST00000545738
• ENSP00000443794

Symbol

• PINCH2
• LGMD2W
• PINCH2
• MDRCMTT
• PINCH-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.81
disease perturbation	0.79
PubMedID	0.64
cellular component	0.62
transcription factor	0.6

Protein Classes

PANTHER Classes

Protein / Structural Protein / Lim And Senescent Cell Antigen-like-containing Domain Protein 2

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Lim And Senescent Cell Antigen-like-containing Domain Protein 2

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Lim And Senescent Cell Antigen-like-containing Domain Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.11   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.11   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0