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Tbio
LIMS2
LIM and senescent cell antigen-like-containing domain protein 2

Protein Summary
Description
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration. This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324938
  • ENSP00000326888
  • ENSG00000072163
  • ENST00000355119
  • ENSP00000347240
  • ENST00000409254
  • ENSP00000386907
  • ENST00000409286
  • ENSP00000386252
  • ENST00000409455
  • ENSP00000386383
  • ENST00000409754
  • ENSP00000386345
  • ENST00000409808
  • ENSP00000386637
  • ENST00000410011
  • ENSP00000387002
  • ENST00000410038
  • ENSP00000386570
  • ENST00000545738
  • ENSP00000443794

Symbol
  • PINCH2
  • LGMD2W
  • PINCH2
  • MDRCMTT
  • PINCH-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
disease perturbation
0.79
PubMedID
0.64
cellular component
0.62
transcription factor
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.18   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.18   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (32)
1 – 10 of 32
ILK
Tchem
Family: Kinase
Novelty: 0.00174752
Score: 0.999
Data Source: Reactome,STRINGDB
PARVB
Tbio
Novelty: 0.05250438
Score: 0.974
Data Source: STRINGDB
PARVA
Tbio
Novelty: 0.00412394
Score: 0.968
Data Source: STRINGDB
LIMS1
Tbio
Novelty: 0.00724253
Score: 0.901
Data Source: STRINGDB
NCK2
Tbio
Novelty: 0.02908657
Score: 0.87
Data Source: STRINGDB
RSU1
Tbio
Novelty: 0.02680644
Score: 0.783
Data Source: STRINGDB
NCK1
Tbio
Novelty: 0.00554007
Score: 0.766
Data Source: STRINGDB
RIPK4
Tchem
Family: Kinase
Novelty: 0.00970161
Score: 0.723
Data Source: STRINGDB
TERF1
Tbio
Family: TF
Novelty: 0.00225772
Score: 0.647
Data Source: STRINGDB
PARVG
Tbio
Novelty: 0.14937655
Score: 0.629
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.18

PubMed score by year
PubTator Score  7.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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