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Tbio
LIMS2
LIM and senescent cell antigen-like-containing domain protein 2

Protein Summary
Description
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration. This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324938
  • ENSP00000326888
  • ENSG00000072163
  • ENST00000355119
  • ENSP00000347240
  • ENST00000409254
  • ENSP00000386907
  • ENST00000409286
  • ENSP00000386252
  • ENST00000409455
  • ENSP00000386383
  • ENST00000409754
  • ENSP00000386345
  • ENST00000409808
  • ENSP00000386637
  • ENST00000410011
  • ENSP00000387002
  • ENST00000410038
  • ENSP00000386570
  • ENST00000545738
  • ENSP00000443794

Symbol
  • PINCH2
  • LGMD2W
  • PINCH2
  • MDRCMTT
  • PINCH-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
disease perturbation
0.79
PubMedID
0.64
cellular component
0.62
transcription factor
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.48   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.48   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
60.4
lymphocyte count
1
1
1
46.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
60.4
lymphocyte count
1
46.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM zinc finger domain containing 2
VGNC:6368
459597
Macaque
LIM zinc finger domain containing 2
699463
Mouse
MGI:2385067
225341
Dog
LIM zinc finger domain containing 2
VGNC:42682
612895
Horse
LIM zinc finger domain containing 2
VGNC:19672
100067531
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM zinc finger domain containing 2
Macaque
LIM zinc finger domain containing 2
Mouse
Dog
LIM zinc finger domain containing 2
Horse
LIM zinc finger domain containing 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (32)
1 – 10 of 32
ILK
Tchem
Family: Kinase
Novelty: 0.00147344
Score: 0.999
Data Source: Reactome,STRINGDB
PARVB
Tbio
Novelty: 0.03825772
Score: 0.974
Data Source: STRINGDB
PARVA
Tbio
Novelty: 0.02736601
Score: 0.968
Data Source: STRINGDB
LIMS1
Tbio
Novelty: 0.00648304
Score: 0.901
Data Source: STRINGDB
NCK2
Tbio
Novelty: 0.02220251
Score: 0.87
Data Source: STRINGDB
RSU1
Tbio
Novelty: 0.01645054
Score: 0.783
Data Source: STRINGDB
NCK1
Tbio
Novelty: 0.00352084
Score: 0.766
Data Source: STRINGDB
RIPK4
Tchem
Family: Kinase
Novelty: 0.00818379
Score: 0.723
Data Source: STRINGDB
TERF1
Tbio
Family: TF
Novelty: 0.00174529
Score: 0.647
Data Source: STRINGDB
PARVG
Tbio
Novelty: 0.08921402
Score: 0.629
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.48

PubMed score by year
PubTator Score  7.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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